[Congenital heart defects of the septa, endocardial cushions and the conotruncus].

Der Pathologe
A M Müller, N Sarioglu

Abstract

During embryological development the heart develops from a simple tube into a complex fully developed heart with four chambers. Hence all congenital heart defects develop before the ninth week of gestation. Currently a steadily increasing number of genetic mutations have been found to be responsible for congenital heart defects. Nevertheless, up to now it has been impossible to diagnose a heart defect just on the basis of molecular pathology. Despite the current excellent prenatal and postnatal ultrasound diagnostics, the post-mortem examination is still the gold standard for the diagnosis of complex heart malformations. However, this requires knowledge of the pathomorphology of the heart malformation in question. Therefore, characteristic and distinguishing features of septal defects including atrioventricular septal defects are presented, especially as the latter are part of complex heart defects, such as conotruncal heart malformations.

References

Feb 1, 1979·The Annals of Thoracic Surgery·T J BergerM E Turner
Dec 1, 1979·British Heart Journal·G P PiccoliR H Anderson
Nov 1, 1976·British Heart Journal·A H CameronM C Castro
Aug 1, 1992·The American Journal of Cardiology·A V Mehta, B Chidambaram
Jun 13, 1966·JAMA : the Journal of the American Medical Association·W J Rashkind, W W Miller
Dec 2, 1996·American Journal of Medical Genetics·T A BeckerM E Pierpont
May 8, 2000·The Annals of Thoracic Surgery·C I TchervenkovS A Tahta
Jun 8, 2000·American Journal of Medical Genetics·J MaedaY Kojima
Sep 1, 2005·Pediatric Cardiology·A KhositsethN Ruangdaraganon
Apr 26, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Makoto NakazawaSatoshi Kusuda
Jul 15, 2006·Cardiology in the Young·Christo I TchervenkovGiovanni Stellin
Oct 15, 2008·Orphanet Journal of Rare Diseases·Paula Martins, Eduardo Castela
Jan 16, 2009·Orphanet Journal of Rare Diseases·Frederique Bailliard, Robert H Anderson
Feb 1, 1947·The Journal of Pediatrics·J A ERGANIAND M CASE

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.