PMID: 16501680Feb 28, 2006Paper

Congenital heart diseases and other major anomalies in patients with Down syndrome

Saudi Medical Journal
Fuad I Abbag

Abstract

To determine the frequency and types of congenital heart diseases (CHDs) and other congenital anomalies among Down syndrome (DS) patients, and the short-term survival rate. This is a retrospective review of 98 DS patients seen in Aseer Central Hospital from July 1994 to June 2005. The clinicians notes, echocardiography reports and operative notes were examined. The mean follow up period was 30 +/- 40.1 months. Ninety-three patients had echocardiography; CHDs were found in 57 patients (61.3%). Ventricular septal defect (VSD) was the most common (33.3%) followed by atrioventricular septal defect (22.8%), atrial septal defect (21.1%), patent ductus arteriosus (14%) and tetralogy of Fallot (5.3%). Three patients (5.3%) developed inoperable obstructive pulmonary vascular disease (OPVD) and 3 were deemed inoperable for other reasons. The CHD was clinically suspected in 96%. The most common noncardiac anomalies were gastrointestinal, affecting 22 patients (22.4%): duodenal atresia 8 patients, imperforate anus 7 patients and Hirschsprung disease 4 patients. Sixteen patients (16.3%) died at a mean age of 19 months, 15 of them (93.8%) had anomalies. The most common CHD in DS is VSD and the most common noncardiac anomaly is gastrointestin...Continue Reading

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
C Rodríguez DehliE García López
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
S F WongC Ward
© 2021 Meta ULC. All rights reserved