Abstract
Congenital hyperthyroidism is a very rare disease. But, for each affected child it has to be considered as a serious condition because of the negative impact of hyperthyroidism on fetal and postnatal development. If the manifestation occurs during fetal life tachycardia, cardiac arrhythmia, growth retardation and, most significant, prematurity are the consequences. Postnatal signs of hyperthyroidism are irritability, tachycardia, hypertension, poor weight gain and thyroid enlargement. Even cardiac failure may occur if hyperthyroidism is severe and treatment not adequate which explains the high early mortality rate of 16%. The main complication of persistent hyperthyroidism in the neonatal period and during infancy is craniosynostosis. Severe developmental delay or even mental retardation can be the consequence of inadequate high T4-levels during fetal and neonatal life. Congenital hyperthyroidism was first recognized in infants born to mothers with Graves' disease. The description of transplacental passage of the maternal thyroid stimulating antibodies elucidated the molecular mechanism in this major group of patients with "autoimmune congenital hyperthyroidism". In contrast to this transient, self-limited character of "autoimm...Continue Reading
Citations
Aug 9, 2003·Obstetrics and Gynecology·Shraga BlazerZe'ev Hochberg
Feb 19, 2002·Molecular and Cellular Endocrinology·Eric A IannaconeR Thomas Zoeller
Jun 13, 2002·Environmental Health Perspectives·Thomas R ZoellerRuby Bansal
Dec 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jan Kvetny, Hedvig Poulsen
Nov 6, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Laura J LeePhilip J Lupo
Nov 24, 2007·Fetal Diagnosis and Therapy·Kasemsri SrisupunditTheera Tongsong
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Dec 14, 2016·PloS One·R Nicole HowieJames J Cray
Mar 15, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·R Thomas Zoeller
Feb 5, 2009·Pediatric Research·Dennis McGonagleMichael F McDermott
Jul 29, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jeremy ChesterSamuel Refetoff
Jun 1, 2001·American Journal of Physical Anthropology·P GagneuxA Varki
Dec 26, 2003·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Lori A Markham, Debra L Stevens
Aug 2, 2007·Obstetrics and Gynecology·Sonja A RasmussenMargaret A Honein
Mar 27, 2001·Clinics in Perinatology·A J Shillingford, S Weiner