PMID: 2512164Nov 1, 1989Paper

Congenital hypothyroidism and partial thyroid hormone unresponsiveness of the pituitary in a patient with congenital thyroxine binding albumin elevation

European Journal of Pediatrics
S L DropG Hennemann

Abstract

We describe a girl who presented at the age of 6 weeks with cardiogenic shock due to congenital hypothyroidism (serum thyroxine (T4) less than 12 nmol/l). Thyroxine replacement therapy was instituted. In spite of high total serum T4 levels, thyroid stimulating hormone (TSH) serum values remained elevated. The raised serum T4 levels were the result of congenital elevation of thyroid binding albumin (TBA). Toxic doses of both T4 and triiodothyronine (T3) normalized the elevated TSH levels indicating that the pituitary is responsive to thyroid hormone, albeit at a higher threshold. In patients with congenital TBA elevation and an altered T4 pituitary response requiring thyroid replacement therapy, the measurement of serum free T4 levels is the parameter of choice to monitor treatment.

References

May 1, 1977·The Journal of Endocrinology·T J VisserG Hennemann
Dec 1, 1975·The Journal of Pediatrics·D W SmithN C Myrianthopoulos
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P R LarsenD H Solomon
Aug 1, 1985·Archives of Disease in Childhood·L N ArcherP G Swift
Mar 18, 1982·The New England Journal of Medicine·M RuizS H Ingbar
Jan 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A RöslerE Cerasi
Jan 1, 1980·American Journal of Diseases of Children·R M SchultzM H MacGillivray
Jan 1, 1981·The Journal of Pediatrics·G P Redmond, L F Soyka

❮ Previous
Next ❯

Citations

Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·D A Fisher, D H Polk
Nov 29, 2012·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Syed Ahmed Zaki, Amit Dolas
Mar 6, 2004·Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·In-Ho JeonPoong-Taek Kim
Sep 25, 2004·Blood·James T B CrawleyDavid A Lane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.