Congenital immunodeficiencies in mice increase susceptibility to urinary tract infection

The Journal of Urology
W J HopkinsD T Uehling

Abstract

Severe combined immunodeficient (SCID), T cell deficient, and immunocompetent mice were challenged intravesically with viable uropathogenic Escherichia coli. In comparison to immunocompetent controls, SCID mice had significantly greater numbers of viable E. coli in their bladders and kidneys 7 days after inoculation. Splenic anti-E. coli antibody-forming cells (AFC) were virtually absent in SCID mice at 7.0 days after infection. Adoptive transfer of spleen cells from E. coli-immunized immunocompetent mice to SCID mice enhanced their resistance to urinary tract infection (UTI), as evidenced by lower bacterial counts in bladder and kidneys following an induced infection. Congenitally T cell deficient nude mice and immunocompetent heterozygous controls had equivalent bladder and kidney infection levels at 2 and 7 days after UTI. Immunocompetency thus appears to play a significant role in resistance to E. coli UTI in this animal model. Since mice deficient only in T cells did not show increased UTI susceptibility, T cell-independent antibody responses may be an important immunologic defense mechanism.

References

Jul 1, 1991·The Journal of Urology·D T UehlingE Balish
Mar 23, 1989·The New England Journal of Medicine·J SheinfeldW R Fair
May 1, 1988·The Journal of Urology·D T UehlingE Balish
Feb 1, 1987·The Journal of Urology·D T UehlingE Balish
Sep 1, 1985·Pediatric Infectious Disease·L J BernsteinA Rubinstein
Jan 1, 1985·Infection·C Svanborg EdénS Michalec
Jun 1, 1973·Urology·F B MahonD T Uehling
Feb 25, 1983·Journal of Immunological Methods·J D Sedgwick, P G Holt
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
Dec 1, 1984·Journal of Medical Microbiology·G GillonM Aronson
Sep 1, 1983·The Journal of Infectious Diseases·A J SchaefferJ S Chmiel
Dec 1, 1982·The Journal of Urology·D T UehlingE Balish
Mar 1, 1983·Immunology Today·T Hunig

❮ Previous
Next ❯

Citations

Nov 18, 2009·Infection and Immunity·Kelsey E Sivick, Harry L T Mobley
Jul 14, 2011·Nature Reviews. Urology·Bryndís RagnarsdóttirCatharina Svanborg
Dec 18, 2014·Current Opinion in Infectious Diseases·Valerie P O'BrienScott J Hultgren
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Praveen ThumbikatDavid J Klumpp
Jun 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
Sep 26, 2013·Mucosal Immunology·M A Ingersoll, M L Albert
Mar 22, 2016·Pathogens·Caitlin N Spaulding, Scott J Hultgren
May 23, 2007·Infection and Immunity·Erin C Hagan, Harry L T Mobley
May 27, 2015·Critical Reviews in Microbiology·Alison J CareyGlen C Ulett
Aug 1, 2009·EcoSal Plus·Harry L T MobleyErin C Hagan
Jun 1, 1994·International Journal of Antimicrobial Agents·O M Korzeniowski
Nov 16, 2021·American Journal of Physiology. Renal Physiology·Nicolas MontalbettiMarcelo D Carattino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.