Congenital leukemia: persistent spontaneous regression in a patient with an acquired abnormal karyotype

Acta Haematologica
R SansoneP Cornaglia-Ferraris

Abstract

Congenital leukemia is a rare disease accounting for about 1% of all leukemias in childhood. While cases associated with Down's syndrome not infrequently show a spontaneous regression, such an event is very rare in non-Down cases and exceptional in those (among the latter) which present clonal cytogenetic alterations in the neoplastic cells. We present the case of a patient with congenital leukemia and an abnormal karyotype (limited to the neoplastic clone), in which an apparently spontaneous and prolonged remission occurred after a relapse.

Citations

Jun 23, 2000·Journal of Pediatric Hematology/oncology·R G GrundyD Atherton
Aug 1, 1992·British Journal of Haematology·H HasleN T Pedersen
May 11, 2002·Leukemia & Lymphoma·D Reinhardt, U Creutzig
Apr 19, 2012·Seminars in Fetal & Neonatal Medicine·Marieke H van der LindenRob Pieters
Apr 9, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M Z Handler, R A Schwartz
Apr 17, 1999·Journal of Pediatric Hematology/oncology·M C FernandezK K Matthay
Sep 4, 1999·Seminars in Perinatology·J E SandeB C Lampkin

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