PMID: 907Dec 1, 1975

Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster

American Journal of Obstetrics and Gynecology
W F Geber, L C Schramm

Abstract

Maternal dose--fetal teratogenic response data were obtained for a variety of narcotic and related compounds by single subcutaneous injections of the drugs into pregnant hamsters during the critical periods of central nervous system organogenesis. The number of abnormal fetuses from females injected with diacetylmorphine (heroin), thebaine, phenazocine, pentazocine, propoxyphene, and methadone increased as the maternal dose of the compounds was increased. By contrast, morphine, hydromorphone, and meperidine produced an increase in the number (per cent) of fetal anomalies only up to a certain maternal dose level. Further increases in maternal dose levels did not produce additional fetal anomalies. Comparative studies of single and multiple maternal doses indicated that diacetylmorphine (heroin) and methadone produced a four- to sixfold increase in fetal anomalies with repetitive doses whereas the percentage of malformed fetuses remained the same with hydromorphone (Dilaudid). The narcotic antagonists nalorphine, naloxone, levallophan, and cyclazocine blocked the teratogenic effects of both single and multiple doses of the narcotics.

Citations

Aug 1, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Matthew C Brennan, William F Rayburn
Oct 3, 2013·Obstetrics and Gynecology·Mahsa M YazdyMartha M Werler
May 16, 2018·EFSA Journal·EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
Jul 1, 1978·Journal of Neurochemistry·I S Zagon, P J McLaughlin
Nov 1, 1993·The International Journal of the Addictions·M Behnke, F D Eyler
Dec 1, 1982·Clinical Pediatrics·N L GoldenR J Sokol
Mar 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kristen A Richards, Thomas Stasko
Apr 17, 2015·Der Anaesthesist·T NinkeT Annecke
Mar 5, 2014·Journal of Midwifery & Women's Health·Sharon Bond
Nov 15, 1977·Experientia·I S Zagon, P J McLaughlin

Related Concepts

Abnormalities, Drug-Induced
Opioids
Fetal Mummification
Fetal Structures
Maternal Mortality
Symoron
Narcotic Antagonists
Structure-Activity Relationship

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