PMID: 2113267Apr 1, 1990Paper

Congenital malformations of the external, middle, and inner ear produced by isotretinoin exposure in mouse embryos

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
B E JarvisK K Sulik

Abstract

Isotretinoin (Accutane), a widely used dermatologic drug, produces severe congenital malformations when used during pregnancy. The isotretinoin teratogen syndrome consists of multiple cardiovascular and craniofacial anomalies, most commonly involving the external ear. This study examined the pathogenesis of isotretinoin teratogenicity in a mouse model, using microdissection and histologic examination of fetal mouse ears after treatment with the drug at various stages of embryonic development. In this study, earlier treatment times frequently produced microtia similar to that seen in affected infants, as well as recognizable patterns of temporal bone and ossicular abnormalities; exposure at a later developmental stage resulted in facial tags with less severely affected ears. Possible teratogenic mechanisms of isotretinoin are discussed. Suitability of the mouse model for studying human congenital craniofacial malformations, such as Goldenhar's and Treacher Collins Syndrome, is also explored.

References

Oct 3, 1985·The New England Journal of Medicine·E J LammerI T Lott
Jun 1, 1986·Teratology·F W RosaF O Kelsey
Jun 1, 1987·American Journal of Medical Genetics·K K SulikB E Jarvis

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Citations

Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
May 1, 1996·Teratology·D A FrenzT R Van De Water
Jun 1, 1997·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·C Jacobsson, G Granström
Mar 31, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sydney C ButtsDorothy A Frenz
May 12, 2006·Journal of Neurobiology·Raymond RomandEri Hashino
Apr 17, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Wei LiuDorothy A Frenz
Nov 26, 2010·American Journal of Medical Genetics. Part a·Dorothy A FrenzAlan Shanske
Apr 15, 2006·The Journal of Comparative Neurology·Raymond RomandEri Hashino
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G GranströmB C Magnusson
Aug 1, 1992·Teratology·D T Burk, C C Willhite
Oct 1, 1996·European Journal of Oral Sciences·C Jacobsson, G Granström
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Dana K Tarka-LeedsJohn M Rogers
Sep 30, 2005·The Annals of Otology, Rhinology, and Laryngology·Philipp M GruenEdgar Bachor
Mar 24, 2006·Mund-, Kiefer- und Gesichtschirurgie : MKG·R StaudenmaierO Driemel
Aug 24, 2017·Journal of Cellular Physiology·Xiaohui LiZongbin Cui
Aug 24, 1999·Developmental Biology·Y Raz, M W Kelley
Dec 5, 2002·Mechanisms of Development·Raymond RomandNorbert B Ghyselinck
Apr 1, 1997·Seminars in Perinatology·M Monga

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