Congenital non-central nervous system malformations in cerebral palsy: a distinct subset?

Developmental Medicine and Child Neurology
Lauren SelfMichael Shevell

Abstract

The aim of this article was to identify and contrast the subset of children with cerebral palsy (CP) and non-central nervous system (CNS) congenital malformations with children with CP but no coexisting non-CNS congenital malformations. A population-based regional comprehensive CP registry was used to identify children with CP who had non-CNS congenital malformations (n = 34; 19 males, 15 females; 22 classified as Gross Motor Function Classification System [GMFCS] levels I-III, 12 as GMFCS level IV or V). Their clinical features were then compared with other children with CP without non-CNS congenital malformations (n = 207; 115 males, 92 females; 138 classified as GMFCS levels I-III, 69 as GMFCS level IV or V). Children with CP and non-CNS congenital malformations did not differ from those without in terms of neurological subtype distribution or functional severity, as measured by the GMFCS. Also, there was no association with previous maternal infections (i.e. toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus 2 [TORCH]), maternal fever, use of illicit substances, asphyxia, neonatal encephalopathy, intraventricular haemorrhage, or septicaemia. The incidence of comorbidities such as convulsions, communication diffic...Continue Reading

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Citations

Jan 15, 2016·Developmental Medicine and Child Neurology·Sarah McIntyreUNKNOWN Australian Cerebral Palsy Register Group
Aug 21, 2013·Seminars in Pediatric Neurology·Michael ShevellMaryam Oskoui
Oct 3, 2017·Developmental Medicine and Child Neurology·Kjersti P JystadTorstein Vik
Jun 19, 2019·Journal of Child Neurology·Shona GoldsmithNadia Badawi
Jan 7, 2020·Developmental Medicine and Child Neurology·Ellen ManlongatGulam Khandaker
Feb 27, 2020·Annual Review of Neuroscience·Thomas M MaynardAnthony-S LaMantia

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