Congenital oligodendroglioma: clinicopathologic and molecular assessment with review of the literature

Case Reports in Pathology
Hope RichardChristine Fuller

Abstract

Oligodendroglioma is an infiltrating glial neoplasm frequently seen in adults. Pediatric oligodendrogliomas are rare, with very few cases presenting in infancy and only rare congenital examples. In contrast to adult oligodendrogliomas, pediatric cases typically lack 1p/19q codeletion. Herein we report a case of WHO grade II oligodendroglioma diagnosed in a 7-month-old male infant. The patient initially presented at 3 months of age with symptoms suspicious for seizure. Initial workup including electroencephalography (EEG), electrocardiogram (EKG), and computed tomography (CT) of the head was negative. His symptoms persisted, and subsequent magnetic resonance imaging (MRI) performed at age of 7 months revealed a 2 cm contrast-enhancing left temporal lobe mass. The mass was excised and the microscopic appearance was that of a classic low grade oligodendroglioma composed of cells with uniformly round nuclei, perinuclear halos, delicate branching capillaries, and an absence of high grade features. Mutant specific (R132H) isocitrate dehydrogenase-1 (IDH1) immunohistochemistry was negative, and the tumor lacked detectable 1p or 19q deletions by fluorescent in situ hybridization (FISH). The onset of neurological symptoms in early infan...Continue Reading

References

Aug 1, 1981·Archives of Neurology·A H Koeppen, R J Cassidy
Aug 15, 1998·Pediatric Neurosurgery·N RazackJ Bruner
Oct 24, 2002·Pediatric Neurology·Wu-Shiun HsiehShih Ming Jung
Jan 16, 2003·Seminars in Neurology·Ruben I Kuzniecky, Robert C Knowlton
May 29, 2003·Journal of Neuropathology and Experimental Neurology·Ravi RaghavanCharles L White
Mar 2, 2005·Acta Neuropathologica·Portia A KreigerJeffrey A Golden
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Apr 25, 2009·Epilepsia·William D GaillardUNKNOWN ILAE, Committee for Neuroimaging, Subcommittee for Pediatric
Jan 13, 2010·Neurology·D T HsiehW D Gaillard
Sep 23, 2011·Neuro-oncology·Vaishali SuriChitra Sarkar
May 9, 2014·The American Journal of Surgical Pathology·Fausto J RodriguezPeter C Burger

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Citations

Mar 21, 2017·Acta Pharmacologica Sinica·Y RajeshMahitosh Mandal
Aug 3, 2021·Experimental Cell Research·Pritam Kumar RoyMahitosh Mandal

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Methods Mentioned

BETA
surgical resection
sedation

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