PMID: 9186430Jun 1, 1997Paper

Congenital periodic alternating nystagmus. Diagnosis and Management

Ophthalmology
L GradsteinH P Goldstein

Abstract

The purpose of the study is to investigate diagnostic criteria and treatment methods for patients with congenital periodic alternating nystagmus (PAN). A retrospective analysis was performed of clinical findings and serial eye movement recordings of patients with congenital PAN. Eighteen patients observed from 1983 through 1996 and diagnosed with congenital PAN are included. Five of these have ocular or oculocutaneous albinism. Nine of the 18 patients were treated. Three had Kestenbaum operations before referral to the authors, one was treated with baclofen, and five had large recessions of the four horizontal recti. The studied parameters included visual acuity (VA) and abnormal head posture (AHP); temporal aspects of PAN cycle, nystagmus waveforms, frequency, amplitude, and velocity; as well as mean foveation fraction, a mean percentage of the nystagmus cycle spent at retinal slip velocities less than 10 degrees per second. The authors diagnosed PAN in 9% of patients with congenital nystagmus, although most had not been diagnosed with PAN before referral, despite changing nystagmus. Sixteen patients had AHP, typically shifting. The PAN cycle was of variable duration, often with asymmetric right- and left-beating components. A...Continue Reading

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Citations

Sep 10, 2013·Middle East African Journal of Ophthalmology·Richard W Hertle
Nov 26, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Matthew J Thurtell, R John Leigh
Jul 27, 2001·Neurologic Clinics·T Z MovsasN J Volpe
Jan 9, 2004·Ophthalmology·Ivan G CastilloSheryl Wizov
Feb 10, 2011·Brain : a Journal of Neurology·Mervyn G ThomasIrene Gottlob
Apr 7, 2009·Journal of Pediatric Ophthalmology and Strabismus·Richard W HertleDongsheng Yang
Dec 24, 2004·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Richard W HertleSusan D Mellow
Aug 17, 2005·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Libe GradsteinWilliam A Gahl
Feb 19, 2013·Vision Research·Harold E Bedell, Scott B Stevenson
Mar 14, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Marzieh Salehi FadardiLarry Allen Abel
Apr 19, 2002·Annals of the New York Academy of Sciences·David SolomonAnupam Mishra
Jul 16, 2005·Ophthalmic Genetics·Richard W HertleAllison Seward
Nov 11, 2010·The American Orthoptic Journal·Richard W Hertle
Oct 5, 2019·Continuum : Lifelong Learning in Neurology·Janet C Rucker
Jan 10, 2001·Current Opinion in Ophthalmology·I Gottlob
Jul 17, 2004·Strabismus·Ibrahim ErbagciNecdet A Bekir
Jul 1, 2019·Journal of Vestibular Research : Equilibrium & Orientation·Scott D Z EggersDavid E Newman-Toker
Apr 25, 2000·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·A Spielmann
Aug 31, 2021·Investigative Ophthalmology & Visual Science·Bing DaiLarry Allen Abel
Jul 16, 2009·Expert Opinion on Pharmacotherapy·Rebecca Jane McLean, Irene Gottlob

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