Congenital Retinal Macrovessel and the Association of Retinal Venous Malformations With Venous Malformations of the Brain

JAMA Ophthalmology
Francesco PichiDavid Sarraf

Abstract

Congenital retinal macrovessel (CRM) is a rarely reported venous malformation of the retina that is associated with venous anomalies of the brain. To study the multimodal imaging findings of a series of eyes with congenital retinal macrovessel and describe the systemic associations. In this cross-sectional multicenter study, medical records were retrospectively reviewed from 7 different retina clinics worldwide over a 10-year period (2007-2017). Patients with CRM, defined as an abnormal, large, macular vessel with a vascular distribution above and below the horizontal raphe, were identified. Data were analyzed from December 2016 to August 2017. Clinical information and multimodal retinal imaging findings were collected and studied. Pertinent systemic information, including brain magnetic resonance imaging findings, was also noted if available. Of the 49 included patients, 32 (65%) were female, and the mean (SD) age at onset was 44.0 (20.9) years. A total of 49 eyes from 49 patients were studied. Macrovessel was unilateral in all patients. Color fundus photography illustrated a large aberrant dilated and tortuous retinal vein in all patients. Early-phase frames of fluorescein angiography further confirmed the venous nature of th...Continue Reading

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Citations

Sep 8, 2018·JAMA Ophthalmology
Jan 9, 2020·European Journal of Ophthalmology·Luisa PierroFrancesco Bandello
Jan 27, 2021·JCI Insight·Jared S RosenblumKarel Pacak
Sep 24, 2020·Archivos de la Sociedad Española de Oftalmología·B Vidal-VillegasE Santos Bueso
Sep 5, 2021·Archivos De La Sociedad Española De Oftalmología·B Vidal-VillegasE Santos Bueso

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