Congenital self-healing histiocytosis presenting as blueberry muffin baby: a case report and literature review

Indian Journal of Dermatology, Venereology and Leprology
Svetlana PopadicMilos Nikolic

Abstract

Congenital self-healing Langerhans cell histiocytosis (CSHLCH), also called as Hashimoto-Pritzker disease, is a rare, benign variant of histiocytosis. Despite the initial dramatic clinical presentation, affected infants are otherwise healthy and skin lesions disappear spontaneously within several weeks to months. We present a case of CSHLCH presenting as blueberry muffin baby. The lesions appeared in the first week of life and lasted 6 months. The follow-up period was 24 months, without any signs of relapse. At the pediatric dermatology unit of our clinic, during the last 20 years, we had 10 children with Langerhans cell histiocytosis and among them only one with CSHLCH. In the literature, we found only 5 newborns with Langerhans cell histiocytosis presenting as blueberry muffin baby, among them only 4 with self-healing CSHLCH. The early recognition of CSHLCH may spare children from redundant and potentially toxic systemic treatment.

Citations

Feb 11, 2014·Annales de dermatologie et de vénéréologie·A Lasek-DuriezP Modiano
Nov 12, 2013·The Journal of Hand Surgery·Katherine J WillardJoshua M Abzug
Apr 9, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M Z Handler, R A Schwartz
Mar 5, 2014·Pediatric Dermatology·Belén Rubio-GonzálezFrancisco Vanaclocha-Sebastián
Feb 13, 2018·Pediatric Dermatology·Margaret H DenninSarah L Stein
Oct 5, 2017·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Fatma Sule AfsarSila Seremet
Jan 13, 2018·The American Journal of Dermatopathology·Sara Cano BaráRicardo Rueda Plata
Feb 26, 2013·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jefferson TerryTheonia K Boyd
Jul 19, 2021·International Journal of Surgery Case Reports·Aakash MishraAshim Gurung
Aug 12, 2021·Indian Journal of Dermatology, Venereology and Leprology·Gaurav MenghaniKapil Vyas

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