Congenital suprabulbar palsy: a distinct clinical syndrome of heterogeneous aetiology

Developmental Medicine and Child Neurology
Poovathinal A Suresh, Cherukunnathu Deepa

Abstract

Congenital suprabulbar palsy is clinically characterized by problems of feeding, swallowing, drooling, and dysarthria. Epilepsy, delayed motor, cognitive, and language development, as well as learning disabilities may co-exist. Aetiology of the syndrome is diverse, yet studies often attribute it to specific entities. We report on nine patients (seven males, two females; age range 2 to 20 years), highlighting the heterogeneous causes of suprabulbar palsy using neuroimaging and emphasizing the need for systematic investigation for early detection and management. We identified patients with symmetrical infarcts involving the perisylvian region, apart from already-recognized conditions, such as congenital bilateral perisylvian syndrome (CBPS; a neuronal migration disorder) and Worster-Drought syndrome. CBPS simulates Foix-Chavany-Marie syndrome in adults because of staged stroke but differs in many respects. Anoxia or ischemia to the developing brain could be a common plausible aetiology. Studies with large groups of patients are required to differentiate the various subgroups and identify essential criteria for diagnosis.

Citations

May 23, 2008·European Journal of Pediatrics·Jean-Jacques BaudonMarie-Paule Vazquez
Feb 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michael C Wilson, Daniel M Laskin
Oct 26, 2012·Developmental Medicine and Child Neurology·Kayal VijayakumarCatherine Devile
Apr 23, 2014·The Journal of Comparative Neurology·Robert J MorecraftWarren G Darling
Oct 15, 2009·Developmental Medicine and Child Neurology·Maria ClarkBrian G R Neville
Mar 5, 2015·Muscle & Nerve·Francis RenaultMarie-Paule Vazquez
Aug 11, 2011·Neuroscience and Biobehavioral Reviews·Frédérique J Liégeois, Angela T Morgan

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