Congenital thrombotic thrombocytopenic purpura (TTP) with placental abruption despite maternal improvement: a case report.

BMC Pregnancy and Childbirth
Marti D SofferIlona T Goldfarb

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a rare but serious complication in pregnancy that places the mother and fetus at high risk for morbidity and mortality. This case illustrates novel pregnancy complications associated with this rare medical condition. A 31-year-old G3P0020 at 28 weeks and 1 day was admitted with severe thrombocytopenia and was ultimately diagnosed with TTP. With therapeutic plasma exchange (TPE), maternal status improved. At 28 weeks 6 days, however, non-reassuring fetal testing prompted cesarean delivery with placental abruption noted intraoperatively. Pathology examination confirmed placental abruption and also revealed multiple placental infarcts. While medical management of TTP can significantly improve the health of the mother, this case highlights the potential role of TTP in abruption and other placental pathology and thus, the need for close fetal surveillance throughout an affected pregnancy.

References

Oct 1, 1996·American Journal of Obstetrics and Gynecology·R S EgermanB M Sibai
May 6, 2008·American Journal of Obstetrics and Gynecology·James N MartinWarren L May
Mar 1, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S DattaL Hanna
May 2, 2012·Blood·Marie Moatti-CohenUNKNOWN French Reference Center for Thrombotic Microangiopathies
May 27, 2014·Blood·Marie ScullyUNKNOWN collaborators of the UK TTP Registry

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Citations

Jul 13, 2021·Microvascular Research·Sepideh Zununi VahedMohammadreza Ardalan

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Methods Mentioned

BETA
cesarean section

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