PMID: 7085242Mar 1, 1982Paper

Congenital toxoplasmosis: histological and ultrastructural study

Italian Journal of Neurological Sciences
F FenziN Rizzuto

Abstract

A case of congenital toxoplasmosis is reported in which the patient died at 32 days following seizures, coma and respiratory disturbances. Neuropathological examination showed numerous foci of softening throughout the brain. Histological examination disclosed widespread areas of inflammatory necrosis. Circumscribed areas of granulomatous inflammation were also found. Cysts containing a variable number of microorganisms and toxoplasmas free in the damaged areas were frequently observed. Small calcifications were scattered in the cerebral cortex and basal ganglia. Electron microscopy of postmortem brain specimens demonstrated toxoplasmas at various stages of development. The microorganism is enveloped by a two-layered membrane, the pellicle. Replication occurs in a vacuole inside the host cell. Following replication the newly formed parasites, the trophozoites, are released. Several replications without release may also occur with consequent cyst formation. The motile form of the toxoplasma, the tachyzoite, is fusiform with truncated cone shape of the anterior ending which is the presenting surface modified for host cell penetration. The modality of transplacental transmission and the clinical syndromes associated with toxoplasma...Continue Reading

References

Apr 1, 1977·Teratology·J W Larsen
Jan 1, 1970·Annual Review of Medicine·J S Remington
May 16, 1974·The New England Journal of Medicine·G Desmonts, J Couvreur
Jan 1, 1967·Advances in Parasitology·L Jacobs
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·W M HutchisonK Work
Jan 13, 1962·British Medical Journal·P C GARNHAMR G BIRD

Related Concepts

Brain
Electron Microscopy
Necrosis
Toxoplasmosis, Fetal

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.