Congenital transmission of experimental leishmaniasis in a hamster model.

The American Journal of Tropical Medicine and Hygiene
Yaneth OsorioBruno L Travi

Abstract

Little information is available on transplacental transmission of Leishmania spp. We determined the frequency and impact of congenital infection caused by Leishmania panamensis or L. donovani in experimentally infected hamsters. A polymerase chain reaction showed that congenital transmission occurred in 25.8% (24 of 93) of offspring born to L. panamensis-infected hamsters and 14.6% (11 of 75) offspring born to L. donovani-infected hamsters. Mortality during lactation was higher in offspring born to L. panamensis-infected hamsters and offspring born to L. donovani-infected hamsters than controls, and lymphoproliferation to Leishmania was more frequent in offspring born to L. panamensis-infected hamsters (17.4%, 11 of 63) than in offspring born to L. donovani-infected hamsters (8.5%, 3 of 35). After weaning, only offspring born to L. donovani-infected hamsters had lower weight gain (P < 0.001) and hematocrit levels (P = 0.0045) than controls. Challenge of offspring born to L. panamensis-infected hamsters with L. panamensis showed no differences in lesion evolution, and offspring born to L. donovani-infected hamsters were more susceptible to L. donovani challenge than controls. Consequently, prenatal exposure of hamsters to L. don...Continue Reading

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Citations

Jan 10, 2013·PLoS Pathogens·Laura-Isobel McCallGreg Matlashewski
Feb 2, 2016·Veterinary Immunology and Immunopathology·Blake VidaChristine A Petersen
Mar 10, 2015·The Journal of Clinical Investigation·Vandana ChaturvediSing Sing Way
Sep 16, 2015·PloS One·Malgorzata BednarskaRenata Welc-Falęciak
Nov 13, 2014·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Italo José Mesquita Cavalcante, Marcus Raimundo Vale
Jun 27, 2013·The American Journal of Tropical Medicine and Hygiene·Miroslava Avila-GarcíaNorma Galindo-Sevilla
Jun 12, 2018·Parasite Immunology·N Galindo-Sevilla, J Mancilla-Ramírez
Sep 6, 2018·Biomédica : revista del Instituto Nacional de Salud·Ángel Jaimes, Gerzaín Rodríguez
Nov 26, 2019·Transboundary and Emerging Diseases·Joaquina Martín-SánchezVictoriano Díaz-Sáez
Aug 1, 2020·Parasite Immunology·Srija MoulikMitali Chatterjee
Nov 20, 2020·Open Forum Infectious Diseases·Yossi Bitton, Orna Diav-Citrin
Dec 31, 2020·Revista Argentina de microbiología·María Belén SánchezDiego Esteban Cargnelutti

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