Congenital tumors of the central nervous system: an institutional review of 64 cases with emphasis on tumors with unique histologic and molecular characteristics.

Brain Pathology
Angela N ViaeneMariarita Santi

Abstract

Congenital brain tumors are rare accounting for 0.5%-1.9% of all pediatric brain tumors. While different criteria have been used to classify a tumor as congenital, those diagnosed prior to 6 months of age are considered to be "probably" congenital in origin. We performed an institutional review of all central nervous system (CNS) tumors (surgical and autopsy specimens from 1990 to 2019) in patients less than 6 months old. Sixty-four unique cases were identified, and these accounted for 2.0% of all CNS tumor specimens at our institution. The most common tumor types were high-grade gliomas, low-grade gliomas and medulloblastomas. Atypical teratoid rhabdoid tumors, choroid plexus tumors and germ cell tumors also accounted for a significant portion of the cohort. Seven tumors were diagnosed prenatally. The most common clinical presentation at diagnosis was increased head circumference. At the conclusion of the study, over half of the patients were alive including all patients with WHO grade I and II tumors. Ninety-two percent of cases were classifiable using the 2016 WHO system, and when available, molecular findings supported the histologic diagnoses. However, several gliomas had unusual histologic features and did not correspond ...Continue Reading

References

Sep 1, 1990·AJR. American Journal of Roentgenology·P C BuetowS Done
Mar 1, 1990·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S OiS Matsumoto
Jan 1, 1986·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·I D EllamsA L Agnoli
Jun 1, 1984·Surgical Neurology·S WakaiM Nagai
Nov 19, 2002·Pediatric Neurology·Hart Isaacs
Dec 31, 2002·Pediatric Neurology·Hart Isaacs
Sep 28, 2004·Journal of Child Neurology·Helen K Young, Heather Johnston
Mar 21, 2006·Archives of Disease in Childhood·S H WilneC R Kennedy
Apr 9, 2008·Journal of Pediatric Hematology/oncology·Joseph L LaskyTheodore Moore
May 7, 2008·European Radiology·M CassartF Avni
Apr 28, 2009·American Journal of Perinatology·Hart Isaacs
Jun 25, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Naveen MehrotraEnrique C G Ventureyra
Nov 13, 2009·Pediatric Neurosurgery·Mohammed F ShamjiJean-Pierre Farmer
Apr 30, 2010·Neuroradiology·Mariasavina SeverinoAndrea Rossi
Oct 12, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tang-Her JaingChen-Kan Tseng
Apr 6, 2011·Journal of Child Neurology·Branavan Manoranjan, John P Provias
Jun 1, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Elżbieta JurkiewiczMałgorzata Syczewska
May 20, 2015·Cellular and Molecular Life Sciences : CMLS·Tao SunJoshua B Rubin
Jun 6, 2015·Pediatrics and Neonatology·Masaya SugimotoHideaki Senzaki
Sep 9, 2015·Pediatric Radiology·Tina Y PoussaintThierry A G M Huisman
Aug 18, 2016·BMJ Case Reports·Yasmin AghajanJohn Ross Crawford
Nov 1, 2016·Nature Medicine·UNKNOWN International Cancer Genome Consortium PedBrain Tumor Project
Nov 28, 2016·Neuroimaging Clinics of North America·Karuna V Shekdar, Erin Simon Schwartz
Feb 3, 2019·BMJ Case Reports·Andrew NgJohn Ross Crawford
May 28, 2019·Genome Medicine·Lea F SurreyMarilyn M Li
Sep 27, 2019·Nature Communications·Ana S Guerreiro StucklinCynthia Hawkins
Dec 26, 2019·Journal of Neuro-oncology·Ahmed GilaniAdam L Green

❮ Previous
Next ❯

Citations

Oct 17, 2020·Brain Tumor Pathology·Konstantin BräutigamEkkehard Hewer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.