Congenital Zika Virus Infection in Immunocompetent Mice Causes Postnatal Growth Impediment and Neurobehavioral Deficits.

Frontiers in Microbiology
Amber M PaulFengwei Bai

Abstract

A small percentage of babies born to Zika virus (ZIKV)-infected mothers manifest severe defects at birth, including microcephaly. Among those who appeared healthy at birth, there are increasing reports of postnatal growth or developmental defects. However, the impact of congenital ZIKV infection in postnatal development is poorly understood. Here, we report that a mild congenital ZIKV-infection in pups born to immunocompetent pregnant mice did not display apparent defects at birth, but manifested postnatal growth impediments and neurobehavioral deficits, which include reduced locomotor and cognitive deficits that persisted into adulthood. We found that the brains of these pups were smaller, had a thinner cortical layer 1, displayed increased astrogliosis, decreased expression of microcephaly- and neuron development- related genes, and increased pathology as compared to mock-infected controls. In summary, our results showed that even a mild congenital ZIKV infection in immunocompetent mice could lead to postnatal deficits, providing definitive experimental evidence for a necessity to closely monitor postnatal growth and development of presumably healthy human infants, whose mothers were exposed to ZIKV infection during pregnancy.

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Citations

Jan 18, 2020·Science Advances·J Barbeito-AndrésP P Garcez
Feb 29, 2020·PloS One·Pedro Massaroni PeçanhaMaria Elisabeth Lopes Moreira
Mar 3, 2020·Frontiers in Immunology·Franciane Mouradian Emidio TeixeiraMaria Notomi Sato
Oct 23, 2020·PLoS Neglected Tropical Diseases·Harish NarasimhanSabra L Klein
Dec 9, 2020·The International Journal of Neuroscience·Ricardo Augusto Leoni De SousaDanilo Bretas de Oliveira

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Datasets Mentioned

BETA
PRJNA385324

Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

GraphPad Prism
Scan IP
ImageJ

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