PMID: 8944822Nov 1, 1996Paper

Congestive heart failure: increased cardiac and extracardiac atrial natriuretic peptide gene expression

Cardiovascular Research
J E PoulosD L Vesely

Abstract

The present investigation was designed to determine if atrial natriuretic peptide (ANP) gene expression increases in extracardiac as well as within the heart in congestive heart failure. Congestive heart failure (CHF) was induced by producing cardiac hypertrophy secondary to an aortocaval fistula in Sprague-Dawley rats. To characterize this model, control and CHF rats had cardiac catheterizations and transthoracic echocardiography. ANP messenger RNA was measured by RNAase protection analysis in atria, ventricles, liver, colon, and stomach of CHF and sham rats and quantitated by 2-D scanning. The product of ANP gene expression was determined in each of these tissues with high performance-gel permeation chromatography. To help determine if increased degradation of atrial natriuretic peptides occur in congestive heart failure, the circulating concentrations and the excretion of the atrial natriuretic peptides into urine were measured by specific radioimmunoassays. ANP steady-state mRNA increased 4.2 +/- 0.05 and 4.3 +/- 0.06-fold, respectively, in the antrum of the stomach and within the heart ventricle of CHF rats compared with age-matched sham rats. ANP gene expression was present but not increased in atria, liver, and gastroint...Continue Reading

Citations

Sep 22, 2007·Current Heart Failure Reports·David L Vesely
Sep 11, 2012·Cardiovascular Research·Shokoufeh MahmoodzadehVera Regitz-Zagrosek
Jun 25, 1999·Metabolism: Clinical and Experimental·D L VeselyR V Farese

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