PMID: 2509529Nov 1, 1989Paper

Congestive heart failure induced by six of the newer antiarrhythmic drugs

Journal of the American College of Cardiology
S RavidB Lown

Abstract

The incidence of drug-induced congestive heart failure with several newer antiarrhythmic agents including encainide, ethmozine, lorcainide, mexiletine, propafenone and tocainide was determined in a group of 407 patients who underwent 1,133 drug tests. The incidence rate ranged from 0.7% with lorcainide to 4.7% with propafenone. Congestive heart failure was present in 167 patients (41%) who underwent 491 drug trials. Congestive failure was induced in 15 (9%) of these 167 patients and involved 19 (3.9%) of the 491 tests. Left ventricular ejection fraction was 20 +/- 8% in patients who developed congestive failure, in contrast to 39 +/- 19% in those who did not (p less than 0.001). It is concluded that each of the six antiarrhythmic drugs examined has the potential to aggravate congestive heart failure in patients with reduced left ventricular ejection fraction or a history of congestive heart failure, but the incidence rate is low and its occurrence unpredictable.

References

Jan 31, 1986·The American Journal of Cardiology·R L WoosleyD M Roden
Aug 29, 1986·The American Journal of Cardiology·L F Soyka
Oct 1, 1985·Journal of the American College of Cardiology·J C RutledgeE A Amsterdam
Mar 1, 1980·Current Problems in Cardiology·B LownT B Graboys
Sep 1, 1982·The American Journal of Cardiology·T B GraboysR DeSilva
Sep 22, 1983·The American Journal of Cardiology·P J Block, R A Winkle
Sep 1, 1984·The American Journal of Cardiology·J SteinB Lown
Dec 1, 1980·American Heart Journal·H R HornM D Young
Mar 13, 1980·The New England Journal of Medicine·P J PodridB Lown

❮ Previous
Next ❯

Citations

Nov 1, 1990·Journal of Clinical Pharmacology·P J Podrid
Nov 1, 1991·Journal of Clinical Pharmacology·H FruminN Kerin
Nov 1, 1991·Journal of Clinical Pharmacology·P J Podrid, T T Fuchs
Feb 1, 1991·Journal of Clinical Pharmacology·E M Vaughan Williams
Jul 1, 1994·Journal of Clinical Pharmacology·E G GiardinaR Sciacca
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·A Auricchio, H Klein
Aug 29, 1996·The American Journal of Cardiology·H L Greene
Nov 1, 1990·Pacing and Clinical Electrophysiology : PACE·P J Podrid
Apr 1, 1992·Pacing and Clinical Electrophysiology : PACE·B S StamblerK A Ellenbogen
Nov 30, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·T Jared Bunch, Jeffrey L Anderson
Feb 10, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Matteo AnselminoFiorenzo Gaita
Feb 19, 2013·Toxicology and Applied Pharmacology·Yusheng QuHugo M Vargas
Dec 1, 1996·Journal of Cardiac Failure·J ToyamaI Kodama
Sep 18, 1997·Japanese Circulation Journal·W G Stevenson, M O Sweeney
Feb 20, 1990·The American Journal of Cardiology·P J Podrid, S L Beau
Jun 4, 1992·The American Journal of Cardiology·P J PodridT T Fuchs
Sep 21, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Carleton B Maxwell, Antoine T Jenkins
Aug 5, 2011·Clinical Pharmacology and Therapeutics·B CharbitC Funck-Brentano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.