Congestive heart failure: involvement of perivascular peptides reflecting activity in sympathetic, parasympathetic and afferent fibres

European Journal of Clinical Investigation
L EdvinssonS Valdemarsson

Abstract

In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and sensory nervous systems, respectively, have been examined. There was a significant rise in the levels of noradrenaline, NPY-LI and SP-LI already in moderate CHF (New York Heart Association Stage I and II). In patients with severe CHF (NYHA Stage III and IV) the circulating levels of noradrenaline, adrenaline, NPY-LI and SP-LI were significantly increased. CGRP-LI was not altered, despite the fact that this peptide co-exists in many tissues with SP. There was no change in VIP-LI. The pathophysiological significance of this pattern of reaction of circulating catecholamines and neuropeptides is unclear; however, the rise in SP-LI may be a reaction to counterbalance the vasoconstrictive effects of the activation of the sympatho-adrenal system.

References

Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
Jan 1, 1986·Acta Physiologica Scandinavica·G Burnstock
Jul 11, 1988·The American Journal of Cardiology·G S Francis
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J McCullochL Edvinsson
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergT Hökfelt

❮ Previous
Next ❯

Citations

Sep 1, 1994·Basic Research in Cardiology·I RubinsteinI H Zucker
Sep 1, 1993·Circulation Research·S GulbenkianL Edvinsson
Jul 25, 2000·European Journal of Clinical Investigation·G N OnuohaD P Nicholls
Jan 1, 1992·European Journal of Clinical Pharmacology·T HednerA Pettersson
Jan 13, 2000·The Journal of Pharmacy and Pharmacology·X H ZhaoT Hedner
Jun 21, 2003·Journal of Hypertension·Carmine ZoccaliLorenzo S Malatino
Aug 13, 2011·Expert Reviews in Molecular Medicine·Asma EjazLeena Pradhan
Feb 1, 1993·European Journal of Clinical Investigation·M M StahlR Ekman
Jun 17, 2008·Journal of Gastroenterology and Hepatology·Reiner WiestRainer Straub
Aug 3, 2010·Heart and Vessels·Yong WangAkira Matsumori
Apr 1, 1996·Pharmacology & Toxicology·O Saetrum Opgaard, L Edvinsson
Feb 19, 2002·British Journal of Clinical Pharmacology·Andrew P Davie, John J V McMurray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.