Conjoint action of phosphatidylinositol and adenylate cyclase systems in serotonin-induced facilitation at the crayfish neuromuscular junction.

Journal of Neurophysiology
D Dixon, H L Atwood

Abstract

1. Pulsatile application of serotonin (5-HT) leads to facilitation of excitatory postsynaptic potentials (EPSPs) in crayfish "opener" neuromuscular preparations. The facilitation resulting from a single application of serotonin shows two phases: an early, rapidly decaying phase, and a less intense, long-lasting phase of 1- to 2-h duration. A previous study implicated the phosphatidylinositol system as an essential component in serotonin-induced facilitation, especially the early phase. The present study was conducted to determine the roles of the adenylate cyclase and phosphatidylinositol systems in both phases of serotonin-induced facilitation. 2. Relatively brief applications of agents known to affect the intracellular concentration of cAMP (forskolin, 1 microM; and IBMX, 100 microM) cause an increase in EPSP amplitude, which persists for 1-2 h. 3. The duration of the less intense, long-lasting phase of serotonin-induced facilitation is prolonged in the presence of 1 microM IBMX. This concentration of IBMX does not affect EPSP amplitude by itself. A membrane-permeant analog of cAMP (applied in concentrations less than or equal to 1 mM) is also not effective in altering EPSP amplitude. However, when dibutyryl cAMP is applied i...Continue Reading

Citations

Oct 12, 2012·Experimental Neurobiology·Wen-Hui Wu, Robin L Cooper
May 28, 2015·Neurochemical Research·John T Hackett, Tetsufumi Ueda
Apr 4, 2002·Journal of Neurophysiology·Lyle E Fox, Philip E Lloyd
Jan 23, 2003·Microscopy Research and Technique·Robin L CooperWendy M Warren
Mar 11, 2000·Journal of Neurophysiology·L E Fox, P E Lloyd
Mar 23, 2004·Journal of Applied Physiology·G M Sparks, R L Cooper
Dec 25, 2002·Journal of Neurobiology·Kathryn S RichardsEve Marder
Aug 7, 2002·British Journal of Pharmacology·Eugen BrailoiuNae J Dun
Jul 29, 2005·Cellular and Molecular Neurobiology·Francisco F De-Miguel, Citlali Trueta
Jul 1, 2004·The Journal of Nutrition·Xue-Lin CuiRonaldo P Ferraris
Mar 28, 2021·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Toshiki Abe, Toshiki Nagayama
Mar 6, 2007·The Journal of Experimental Biology·Jonna L HamiltonMary Kate Worden
Mar 26, 2002·Brain Research·Jami N Tabor, Robin L Cooper
Jul 7, 2000·Brain Research·R C SouthardR L Cooper
Jan 13, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B GriffisR L Cooper
Apr 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J R StrawnR L Cooper
Jan 1, 1993·Journal of Physiology, Paris·R S Zucker
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Maurice-Pierre Pagé, Robin L Cooper
Sep 14, 2011·Brain Research·Marlen Valdés-FuentesMaría Luisa Fanjul-Moles

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.