Conjugal transformed mycosis fungoides: the unknown role of viral infection and environmental exposures in the development of cutaneous T-cell lymphoma

Journal of the American Academy of Dermatology
Adriana N SchmidtJohn A Zic

Abstract

The etiology of mycosis fungoides (MF) is uncertain, although infectious agents and other environmental exposures have been implicated. We describe what appears to be the first case in which both a husband and his wife were diagnosed with large-cell transformation of MF. After 10 years of having stage I MF, the wife developed tumors that showed sheets of large transformed cells with dysplastic nuclei on skin biopsies, leading to a diagnosis of transformed MF. Her husband was diagnosed 14 months later with transformed MF following a biopsy of his right arm and leg after a 15-year history of presumed psoriasis. The fact that this rare occurrence happened in a couple who had been married for more than 25 years points to a common environmental exposure. Future studies should aim to clarify the potential role of infectious agents, such as human T-lymphotropic virus I and II, cytomegalovirus, Epstein-Barr virus, and other environmental exposures, in the development of MF.

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Citations

Jun 29, 2013·Clinics in Dermatology·Judah J MirvishLarisa J Geskin
Jan 21, 2012·Journal of the American Academy of Dermatology·Jennifer L Herrmann, Lauren C Hughey
Feb 24, 2007·Journal of the American Academy of Dermatology·Annabelle Lozano, Madeleine Duvic
Dec 2, 2014·Journal of the American Academy of Dermatology·Ioanna TriantafyllopoulouChristina Antoniou
Jun 19, 2007·The British Journal of Dermatology·E BarberioS Dalle
Sep 23, 2008·Experimental Dermatology·Gaëlle QuéreuxBrigitte Dréno
Apr 1, 2018·Experimental Dermatology·Jürgen BrückKamran Ghoreschi
Dec 21, 2016·Current Hematologic Malignancy Reports·Anh PhanMary Jo Lechowicz
Aug 22, 2020·Journal of the American Academy of Dermatology·Amrita GoyalMurali Janakiram
May 21, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A GoyalM Janakiram

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