Conjugated bile acid replacement therapy in short bowel syndrome patients with a residual colon

Zeitschrift für Gastroenterologie
C KapralAlan F Hofmann

Abstract

To test the efficacy of cholylsarcosine (synthetic conjugated bile acid) and ox bile extracts (mixture of natural conjugated bile acids) on fat absorption, diarrhea, and nutritional state in four short bowel syndrome (SBS) patients with a residual colon not requiring parenteral alimentation. The effect of cholylsarcosine (2 g/meal) on steatorrhea and diarrhea was examined in short-term balance studies with a constant fat intake in all four patients. The effect of continuous cholylsarcosine ingestion on nutritional state was assessed by changes in body weight in three patients. In two patients, the effects of cholylsarcosine were compared with those of ox bile extracts. Because of the low incidence rate of SBS this is not a controlled study. In balance studies, cholylsarcosine increased fat absorption from 65.5 to 94.5 g/day (a 44 % increment), an energy gain of 261 kcal/d. Fecal weight increased by 26 %. In two patients natural conjugated bile acids also reduced steatorrhea, but greatly increased diarrhea. As outpatients consuming an unrestricted diet and ingesting cholylsarcosine, three patients gained weight at an average rate of 0.9 kg/week without worsening of diarrheal symptoms. Cholylsarcosine is efficacious and safe for ...Continue Reading

Citations

Sep 20, 2005·Current Gastroenterology Reports·Christian Jackson, Alan L Buchman
Oct 7, 2008·World Journal of Gastroenterology : WJG·Olga Martinez-Augustin, Fermin Sanchez de Medina
Dec 25, 2007·Wiener klinische Wochenschrift·Peter PiringerKurt Lenz
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Jun 22, 2016·Current Gastroenterology Reports·Robert E CarrollAlan L Buchman
Feb 14, 2006·Gastroenterology·Alan L Buchman
Mar 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan F Hofmann
Jan 28, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Vanessa J Kumpf
Jun 14, 2006·Journal of Clinical Gastroenterology·Laura E Matarese, Ezra Steiger

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