Conjugated equine estrogen and medroxyprogesterone acetate are associated with decreased risk of breast cancer relative to bioidentical hormone therapy and controls

PloS One
Zexian ZengRichard Neapolitan

Abstract

By the 1990s it became popular for women to use hormone therapy (HT) to ease menopause symptoms. Bioidentical estrogen and progesterone are supplements whose molecular structures are identical to what is made in the human body, while synthetic supplements are ones whose structures are not. After the Women's Health Initiative found that the combined use of the synthetics conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increased breast cancer risk, prescriptions for synthetic HT declined considerably. Since then there has been an increased interest in bioidentical HT; today there are a plethora of websites touting their benefits. However, no peer-reviewed articles support these claims. We performed a retrospective study with the objective of verifying the hypothesis that bioidentical HT is associated with decreased breast cancer risk than CEE & MPA. We searched The Northwestern Medicine Enterprise Data Warehouse for women who initiated HT use after age 50. Women who did not take any HT drug after age 50 served as controls. Nine HT protocols were investigated for breast cancer risk. Significant results include CEE Alone is associated with decreased breast cancer risk (HR = 0.31), Other Synthetic Estrogen Alo...Continue Reading

References

Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Jan 8, 2004·JAMA : the Journal of the American Medical Association·Adam L HershRandall S Stafford
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Agnès FournierFrançoise Clavel-Chapelon
Dec 2, 2006·Obstetrics and Gynecology·Heli LyytinenOlavi Ylikorkala
Dec 24, 2008·Obstetrics and Gynecology·Heli LyytinenOlavi Ylikorkala
Jun 23, 2010·The Journal of Clinical Endocrinology and Metabolism·Richard J SantenUNKNOWN Endocrine Society
Oct 21, 2010·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Andrea Z LaCroixUNKNOWN WHI Investigators
May 3, 2011·Mayo Clinic Proceedings·Julia A FilesSandhya Pruthi
Jan 30, 2014·International Journal of Women's Health·Richa SoodLynne T Shuster
Feb 17, 2015·JAMA Internal Medicine·Nancy E AvisUNKNOWN Study of Women's Health Across the Nation
Jun 27, 2017·Menopause : the Journal of the North American Menopause Society·UNKNOWN The NAMS 2017 Hormone Therapy Position Statement Advisory Panel

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Citations

Oct 13, 2019·International Journal of Dermatology·Amanda RosenthalRonald Moy

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