Conjugated linoleic acid (CLA), body fat, and apoptosis

Obesity Research
Jess MinerClifton A Baile

Abstract

The objective of the study was to determine if consumption of conjugated linoleic acid (CLA) by mice could induce apoptosis in adipose tissue. Other objectives were to determine the influence of feeding mice CLA for < or =2 weeks on body fat, energy expenditure, and feed intake. A mixture of CLA isomers (predominantly c9,t11 and t10,c12) was included in the AIN-93G diet at 0, 1, and 2%, and fed to mice for 12 days (Trial 1), or was included at 2% and fed to mice for 0, 5, and 14 days (Trial 2). Feed intake was measured daily and energy expenditure was determined by direct calorimetry on day 9 in Trial 1. Retroperitoneal fat pads were analyzed for apoptosis by determination of DNA fragmentation. Dietary CLA reduced feed intake by 10% to 12% (p < 0.01), but either did not influence or did not increase energy expenditure as indicated by heat loss. Body weight was not influenced by consumption of CLA in Trial 1 but was increased (p < 0.01) by CLA in Trial 2. Weights of retroperitoneal, epididymal, and brown adipose tissues were lower (p < 0.01) in animals fed CLA, although liver weight was increased (p < 0.10; Trial 1) or not changed (Trial 2). Analysis of retroperitoneal fat pad DNA from both trials indicated that apoptosis was in...Continue Reading

References

May 16, 1997·Science·J Himms-Hagen
Apr 16, 1998·Biochemical and Biophysical Research Communications·K L HouseknechtM A Belury

❮ Previous
Next ❯

Citations

Jul 22, 2009·The British Journal of Nutrition·Jonatan MirandaMaría Puy Portillo
Nov 21, 2007·Public Health Nutrition·Manuela-Belén SilveiraJavier Tébar
Apr 1, 2010·The Journal of Biological Chemistry·Kristina MartinezMichael McIntosh
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Syam MohanManal Mohamed Elhassan
Aug 13, 2013·Research in Veterinary Science·S HäusslerH Sauerwein
Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·Simona SeriniGabriella Calviello
Aug 18, 2012·Metabolism: Clinical and Experimental·Gustavo D PimentelJosé B C Carvalheira
May 24, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Paula A LopesJosé A M Prates
Oct 16, 2004·Obesity Research·Kimberly M HargraveJess L Miner
Sep 16, 2003·Obesity Research·Kimberly M HargraveJess L Miner
Aug 23, 2008·Obesity·Kimberly M Hargrave-BarnesJess L Miner
Apr 15, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rebecca KlossMark Kern
Dec 29, 2004·Physiology & Behavior·M S Westerterp-Plantenga
May 20, 2015·European Journal of Pharmacology·Monica ViladomiuJosep Bassaganya-Riera
Dec 20, 2002·Obesity Research·Kimberly M HargraveClifton A Baile
Jul 20, 2016·Annual Review of Nutrition·Wan Shen, Michael K McIntosh
Dec 4, 2009·The Journal of Nutritional Biochemistry·Arion KennedyMichael McIntosh
Sep 25, 2003·European Journal of Clinical Nutrition·M M J W KamphuisM S Westerterp-Plantenga
Aug 16, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu CaoYonghua Wang
Feb 29, 2008·Molecular Nutrition & Food Research·Jing-Jing LiDong Xie
Aug 19, 2009·Journal of Veterinary Science·Jin-Joo HueBeom Jun Lee
Jan 16, 2007·Journal of Physiology and Biochemistry·V NavarroM P Portillo
Jul 28, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R L HouseJ Odle
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M M J W KamphuisM S Westerterp-Plantenga
Jan 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Seung-Jin KimBin Gao
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Jul 4, 2001·The Journal of Biological Chemistry·K HottaY Matsuzawa
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Enrique RodríguezAndreu Palou
Jan 24, 2018·Critical Reviews in Food Science and Nutrition·Tyler Maher, Miriam E Clegg
Sep 8, 2007·The American Journal of Clinical Nutrition·Rachel N CloseElizabeth H Nora
Oct 13, 2006·World Journal of Gastroenterology : WJG·Anatol PanasiukDanuta Prokopowicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis