Abstract
A 46-year-old female patient was referred to our department with presenting symptoms of asthenia, jaundice, and pruritus. There was no medical history or clinical evidence of viral hepatitis, autoimmune hepatitis, hemochromatosis, or Wilson's disease. The patient revealed that 14 days prior to admission she had begun self-medicating with conjugated linoleic acid (CLA) to reduce body fat, leading to the suspicion of CLA hepatotoxicity, which was subsequently confirmed by a liver biopsy. After the patient ceased to ingest CLA, liver enzymes levels normalized. To the best of our knowledge, this is the first report of hepatotoxicity due to CLA ingestion.
References
Nov 1, 1993·Journal of Clinical Epidemiology·G Danan, C Benichou
Jan 1, 1997·Journal of Hepatology·D Larrey
Mar 23, 2000·Journal of Hepatology·D Larrey
Mar 24, 2000·Pharmacotherapy·J I Boullata, A M Nace
May 23, 2002·Seminars in Liver Disease·Dominique Larrey
Dec 18, 2002·Annals of Internal Medicine·George OstapowiczUNKNOWN U.S. Acute Liver Failure Study Group
Mar 10, 2005·European Journal of Gastroenterology & Hepatology·Gunda MillonigWolfgang Vogel
Aug 12, 2005·World Journal of Gastroenterology : WJG·Vanessa StadlbauerRudolf E Stauber
Citations
Jun 24, 2003·Chemistry and Physics of Lipids·O LoreauJ P Noël
Mar 29, 2012·Critical Reviews in Food Science and Nutrition·Allison Dilzer, Yeonhwa Park
Jul 6, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kosta CvijovicUNKNOWN SONAR group
Jan 19, 2011·European Journal of Clinical Pharmacology·Annabella VitaloneGabriela Mazzanti
Feb 5, 2016·Lipids in Health and Disease·Anke JaudszusGerhard Jahreis
Jan 6, 2016·Lipids·Yoo KimYeonhwa Park
Oct 9, 2013·Clinics in Liver Disease·Victor J Navarro, Leonard B Seeff
Jul 19, 2011·The Journal of Nutritional Biochemistry·Benjamin J BeldaJohn P Vanden Heuvel
May 24, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Paula A LopesJosé A M Prates
Jan 7, 2016·Annual Review of Food Science and Technology·Jun Ho KimYeonhwa Park
May 13, 2015·Journal of Food Science·Jun Ho KimYeonhwa Park
May 16, 2015·Archives of Toxicology·Gabriela MazzantiAnnabella Vitalone
Aug 5, 2015·Case Reports in Hepatology·Mohammad BilalMichael Babich
Apr 14, 2016·International Journal of Molecular Sciences·Miren García-CortésRaul J Andrade
Jul 13, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy Christine Brown
May 28, 2019·Frontiers in Pharmacology·Qihui WuJiansong Fang
Jun 12, 2020·Phytotherapy Research : PTR·Genario SantosRaul J Andrade
Jun 21, 2020·Nutrients·Edyta MądryAleksandra Lisowska
Nov 30, 2019·Advances in Nutrition·Antwi-Boasiako Oteng, Sander Kersten
Jan 31, 2015·Journal of Agricultural and Food Chemistry·Gaofeng YuanDuo Li
Aug 10, 2017·Journal of Agricultural and Food Chemistry·Luís M Rodríguez-AlcaláMaría-Aránzazu Martínez