Conjugated linoleic acid modulation of risk factors associated with atherosclerosis.

Nutrition & Metabolism
Yukiko K NakamuraStanley T Omaye

Abstract

Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial effect on sclerotic lesions associated with atherosclerosis, be a possible anti-carcinogen, increase feed efficiency, and act as a lean body mass supplement. However, the results have been inconsistent, and the effects of CLA on atherogenesis appear to be dose-, isomer-, tissue-, and species-specific. Similarly, CLA trials in humans have resulted in conflicting findings. Both the human and animal study results may be attributed to contrasting doses of CLA, isomers, the coexistence of other dietary fatty acids, length of study, and inter-and/or intra-species diversities. Recent research advances have suggested the importance of CLA isomers in modulating gene expression involved in oxidative damage, fatty acid metabolism, immune/inflammatory responses, and ultimately atherosclerosis. Although the possible mechanisms of action of CLA have been suggested, they have yet to be determined.

References

Feb 1, 1992·The American Journal of Clinical Nutrition·L G ClelandR A Gibson
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S D CushingA M Fogelman
Jul 1, 1994·Atherosclerosis·K N LeeM W Pariza
Mar 27, 1996·Biochemical and Biophysical Research Communications·E S Collie-Duguid, K W Wahle
Mar 1, 1997·General Pharmacology·A E Simpson
Apr 29, 1998·Journal of the American College of Nutrition·H T Bowen, S T Omaye
Jan 20, 1999·Proceedings of the Association of American Physicians·J M Gaziano
Jul 30, 1999·Biochemical and Biophysical Research Communications·S HiroiA Kimura
Oct 16, 1999·Circulation Research·C Kunsch, R M Medford
Nov 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A JonesR U Pendlington
Jan 5, 2000·The American Journal of Clinical Nutrition·R De CaterinaP Libby
Feb 23, 2000·FEBS Letters·S BasuB Vessby
Aug 24, 2000·Journal of Agricultural and Food Chemistry·L YangZ Y Chen
Aug 30, 2000·Journal of the American College of Nutrition·D KritchevskyS K Czarnecki
Sep 23, 2000·JAMA : the Journal of the American Medical Association·S LiuW C Willett
Sep 30, 2000·The American Journal of Clinical Nutrition·D R Jacobs, M A Murtaugh
Sep 30, 2000·The American Journal of Clinical Nutrition·J P DeLanyG A Bray
Feb 17, 2001·The Journal of Nutritional Biochemistry·P Zhang, S T. Omaye
Aug 14, 2001·Journal of Cellular Biochemistry·C NapoliW Palinski
Dec 19, 2001·The Journal of Biological Chemistry·Donald B Jump
Jan 31, 2002·Annual Review of Medicine·Joel Berger, David E Moller
May 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·E S TaiJ M Ordovas
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·David W SteppKirkwood A Pritchard
Jul 19, 2002·The New England Journal of Medicine·Stefan KiechlDavid A Schwartz
Sep 12, 2002·Trends in Molecular Medicine·Caroline DuvalBart Staels
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Dec 7, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y IwakiriK G D Allen
Dec 7, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J Bassaganya-RieraD C Beitz
Dec 13, 2002·The New England Journal of Medicine·Graham S CookeUNKNOWN Oxford Pneumococcal Surveillance Study Group

❮ Previous
Next ❯

Citations

Dec 17, 2010·Lipids·Alan A HennessyCatherine Stanton
Jul 23, 2009·The British Journal of Nutrition·Robert Ringseis, Klaus Eder
Sep 19, 2009·Nutrition & Metabolism·Sailas Benjamin, Friedrich Spener
Jun 21, 2012·Nutrition & Metabolism·Yukiko K Nakamura, Stanley T Omaye
Jan 8, 2014·Iranian Red Crescent Medical Journal·Javad Zavar RezaMir Saeed Yekaninejad
Sep 11, 2010·Journal of Pharmaceutical and Biomedical Analysis·Min HongJin-ao Duan
Dec 9, 2015·The Proceedings of the Nutrition Society·Laura Wyness
Apr 12, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yukiko K NakamuraStanley T Omaye
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C M Reynolds, H M Roche

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis