Conjugated linoleic acid preserves muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma

Research in Nursing & Health
Donna O McCarthy, Erin Graves

Abstract

Conjugated linoleic acid (CLA), which is found in dairy products, reduces synthesis of tumor necrosis factor-alpha (TNFa), a pro-inflammatory cytokine that plays a major role in tumor-induced skeletal muscle wasting (SMW). The B16 melanoma expresses TNFa mRNA, and induced SMW with no change in muscle levels of TNFa type 1 receptor (TNFR1) protein. A diet containing .5% CLA had no effect on SMW or TNFR1 in mice bearing B16 tumors. In contrast, the Lewis lung carcinoma expresses low levels of TNFa mRNA, induced SMW, and increased muscle levels of TNFR1. A diet containing .5% CLA reduced SMW, but had no effect on muscle levels of TNFR1. We conclude that that tumor-induced SMW can occur independent of muscle levels of TNFR1. Further study is needed before CLA can be tested in persons with cancer cachexia.

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Dec 31, 2004·Research in Nursing & Health·Erin GravesDonna O McCarthy
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Citations

Jun 19, 2007·European Journal of Pharmacology·Sun Jin Hur, Yeonhwa Park
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Pontus M A Siren, Matti J Siren
Feb 18, 2015·Cancer Nursing·Ann O'Mara
Jan 9, 2021·Frontiers in Nutrition·Wouter R P H van de WorpRamon C J Langen

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