Conjugated Polyimine Dynamers as Phase-Sensitive Membrane Probes

Journal of the American Chemical Society
Naomi Sakai, Stefan Matile

Abstract

In this report, dynamic polyimines are introduced as multifunctional sensors of lipid bilayer phases. Under mildly acidic conditions, self-condensation of push-pull amino formyl fluorenes into polyimines occurs in solid- or liquid-ordered phases but not in liquid-disordered phases of vesicular membranes. The obtained conjugated polymers are characterized by a progressive red shift of the absorption maxima, the appearance of exciton-coupled circular dichroism (CD) bands, and fluorescence quenching. These characteristics allow multiple modes of detection of membrane phases, which are known to change under membrane tension.

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Citations

Dec 5, 2020·ACS Central Science·Tobias Schnitzer, Ghislaine Vantomme
Oct 1, 2021·Chemistry : a European Journal·Yixin ChenHao Li
Dec 19, 2021·Chimia·Lea AssiesStefan Matile

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