Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance

ACS Applied Materials & Interfaces
Jingxiao TianYongqiang Cheng

Abstract

The emergence of drug-resistant bacteria severely challenges the antimicrobial agents and antibacterial strategy. Here, we demonstrate a novel, simple, and highly efficient combination therapy strategy by direct combinations of cationic conjugated polymers (CCPs) with polypeptide antibiotics against Gram-negative and Gram-positive bacteria based on a synergistic antibacterial effect. The combination therapy method enhances the antibacterial efficacy with a significantly reduced antibiotic dosage. Also, the highly efficient and synergistic killing of drug-resistant bacteria is realized. Using combinations of CCPs and antibiotics to show increased antibacterial activity, this strategy will provide a much wider scope of the discovery of efficient antibacterial systems than that of antibiotic-antibiotic combinations. The proposed combination therapy method provides a universal and powerful platform for the treatment of pathogens, in particular, the drug-resistant bacteria, and also opens a new way for the development of efficient antibacterial systems.

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Citations

Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Indu SinghP Kumar
Jan 13, 2021·ACS Infectious Diseases·Rashin Namivandi-ZangenehCyrille Boyer
Mar 24, 2020·ACS Applied Materials & Interfaces·Qi JiangYongqiang Cheng
Oct 4, 2019·Chemical Reviews·Regina C So, Analyn C Carreon-Asok

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