PMID: 7541249Mar 1, 1995Paper

Conjugation of adenine arabinoside 5'-monophosphate to arabinogalactan: synthesis, characterization, and antiviral activity

Bioconjugate Chemistry
P EnriquezB C Tennant

Abstract

A conjugate consisting of the antiviral nucleotide analogue adenine arabinoside 5'-monophosphate (araAMP, vidarabine monophosphate) and the naturally occurring polysaccharide arabinogalactan was synthesized. The conjugate consisted of 7.9 araAMP residues per molecule of arabinogalactan. The proposed structure of the conjugate was consistent with 13C NMR spectroscopic studies. Daily injections of the conjugate, at a dose of 3 mg of araAMP/kg, into woodchuck carriers of woodchuck hepatitis virus (WHV) decreased serum levels of WHV DNA. A dose of 3 mg/kg of unconjugated araAMP was ineffective, while a higher dose of araAMP (15 mg/kg, 14 days) produced a drop in WHV DNA. After cessation of dosing with the conjugate, serum viral DNA levels remained depressed for 42 days. In contrast, after cessation of dosing with araAMP, WHV DNA rapidly returned to original levels.

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Citations

Jun 27, 2000·International Journal of Pharmaceutics·Y KaneoT Uemura
Jun 15, 2001·ILAR Journal·B C Tennant, J L Gerin
Apr 30, 2014·Expert Opinion on Drug Delivery·Luigi FiumeGiuseppina Di Stefano
Nov 22, 2005·Expert Opinion on Drug Delivery·Lucija VirovicGeorge Y Wu
Oct 27, 2004·International Journal of Pharmaceutics·Tetsuro TanakaYoshiharu Kaneo
Oct 21, 1999·Journal of Structural Biology·J F HainfeldM Barcena
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E A BiessenT J Van Berkel

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