Jun 10, 2003

Conjugative plasmid transfer in gram-positive bacteria

Microbiology and Molecular Biology Reviews : MMBR
E GrohmannM Espinosa

Abstract

Conjugative transfer of bacterial plasmids is the most efficient way of horizontal gene spread, and it is therefore considered one of the major reasons for the increase in the number of bacteria exhibiting multiple-antibiotic resistance. Thus, conjugation and spread of antibiotic resistance represents a severe problem in antibiotic treatment, especially of immunosuppressed patients and in intensive care units. While conjugation in gram-negative bacteria has been studied in great detail over the last decades, the transfer mechanisms of antibiotic resistance plasmids in gram-positive bacteria remained obscure. In the last few years, the entire nucleotide sequences of several large conjugative plasmids from gram-positive bacteria have been determined. Sequence analyses and data bank comparisons of their putative transfer (tra) regions have revealed significant similarities to tra regions of plasmids from gram-negative bacteria with regard to the respective DNA relaxases and their targets, the origins of transfer (oriT), and putative nucleoside triphosphatases NTP-ases with homologies to type IV secretion systems. In contrast, a single gene encoding a septal DNA translocator protein is involved in plasmid transfer between micelle-f...Continue Reading

  • References141
  • Citations270

Citations

Mentioned in this Paper

Gram-Positive Bacteria
Microorganism
Conjugation
Genes
Homologous Sequences, Amino Acid
Process of Secretion
Intensive Care Unit
Gram-Negative Bacteria
Sequence Analysis
Homologous Sequences, Nucleic Acid

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