Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers.

American Journal of Physiology. Cell Physiology
Andrew Leask

Abstract

Cellular communication network (CCN) proteins are matricellular proteins that coordinate signaling among extracellular matrix, secreted proteins, and cell surface receptors. Their specific in vivo function is context-dependent, but they play profound roles in pathological conditions, such as fibrosis and cancers. Anti-CCN therapies are in clinical consideration. Only recently, however, has the function of these complex molecules begun to emerge. This review summarizes and interprets our current knowledge regarding these fascinating molecules and provides experimental evidence for their utility as therapeutic targets.

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Citations

Apr 23, 2020·American Journal of Physiology. Cell Physiology·Olga Stenina-Adognravi, Josephine C Adams
Aug 7, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carol Feghali-Bostwick
May 16, 2020·Journal of Cell Communication and Signaling·Andrew Leask
Jul 10, 2020·International Journal of Molecular Sciences·Daniel Feng, Casimiro Gerarduzzi
Jul 27, 2020·Journal of Cell Communication and Signaling·Andrew Leask
Nov 23, 2020·Journal of Cellular Physiology·Chao SunXinhui Liu
Jan 1, 2021·International Journal of Molecular Sciences·Stephan Niland, Johannes A Eble
Jan 8, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Andrew Leask
Jan 12, 2021·Journal of Cell Communication and Signaling·Roos J LeguitRoel Goldschmeding
Jan 30, 2021·Cell and Tissue Research·Andrea E DillingerRudolf Fuchshofer
Jan 9, 2021·Journal of Cell Communication and Signaling·Sukhbir Kaur, David D Roberts
Jan 6, 2021·Journal of Cell Communication and Signaling·Xu Shi-WenAndrew Leask
Mar 4, 2021·Journal of Cellular Physiology·Tomomi MizukawaSatoshi Kubota
Apr 21, 2021·Journal of Cell Communication and Signaling·Herman Yeger, Bernard Perbal

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