PMID: 9442798Jan 27, 1998Paper

Conjunctival amelanotic malignant melanoma arising in primary acquired melanosis sine pigmento

Ophthalmology
V Jay, R L Font

Abstract

The authors describe an amelanotic malignant melanoma of the conjunctiva in association with primary acquired melanosis (PAM) sine pigmento, and highlight the clinical and pathologic features of this rare entity. Histopathologic and immunohistochemical studies were performed on a conjunctival tumor in a 54-year-old white woman. Case report. Histopathologic examination revealed an invasive amelanotic melanoma of the conjunctiva, with anterior orbital extension arising from intraepithelial dysplastic melanocytes that lacked melanin pigment (PAM sine pigmento). Both the malignant melanoma cells and the intraepithelial dysplastic melanocytes in the areas of PAM exhibited S-100 and HMB-45 positivity. The patient underwent an orbital exenteration that disclosed tumor within the anterior orbit inferiorly. Amelanotic invasive malignant melanoma can arise in association with PAM sine pigmento, as seen in our patient who had orbital invasion necessitating exenteration. This aggressive form of conjunctival melanoma is often associated with a poor prognosis and risk of metastatic disease. Absence of conjunctival pigmentation in PAM sine pigmento prevents early clinical detection of this variant of PAM. This lack of pigmentation also makes ...Continue Reading

References

Mar 1, 1992·The British Journal of Ophthalmology·A D ParidaensJ L Hungerford

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Citations

Nov 11, 2008·Japanese Journal of Ophthalmology·Takashi NabeshimaDaijiro Kurosaka
Mar 3, 2001·American Journal of Ophthalmology·A NaseriP Paglen
Jan 4, 2001·Clinical Eye and Vision Care·K T CorcoranD C Ward
Aug 26, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Abelardo A Rodríguez-ReyesAlfredo Gómez-Leal
Nov 12, 2015·American Journal of Ophthalmology·Frederick A Jakobiec
Nov 13, 2010·Optometry : Journal of the American Optometric Association·Kathryn D Nelson, John J McSoley
Jun 24, 2008·Cancer Investigation·Mahmoud R Hussein
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Danah H AlbreikiJames P Farmer
Jun 21, 2016·Survey of Ophthalmology·Gargi K VoraPrithvi Mruthyunjaya
Jun 10, 2010·Current Opinion in Ophthalmology·Yevgeniy Shildkrot, Matthew W Wilson
Nov 30, 2016·International Ophthalmology Clinics·Jeanie LingSahar Kohanim

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