Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models

International Journal of Pharmaceutics
Hamdy AbdelkaderRaid G Alany

Abstract

This study aimed at combining the hen's egg test-chorioallantoic membrane (HET-CAM), bovine corneal opacity and permeability (BCOP) test and histological examination of excised corneas to evaluate the conjunctival and corneal toxicity of niosomes and their ingredients. Various surfactant/lipid combinations and concentrations (1-10%, w/v) were investigated for the ocular delivery of an ambitious drug (naltrexone hydrochloride) for treatment of diabetic keratopathy. Four niosomal formulations were investigated and found to be non irritant to the 10 days old HET-CAMs (an acceptable conjunctival model). Only one of the tested ingredients (sodium cholate - CH) showed moderate irritation, however such an effect was diminished when incorporated into niosomes. Corneal opacity and fluorescein permeability scores for the test substances correlated well with the HET-CAM test results. Corneal erosion and stromal thickness were found to be in agreement with the HET-CAM and BCOP results, which discriminated well between moderately and mildly irritant test substances. Corneal histological examination revealed toxicity signs included epithelial erosion, stromal condensation and stromal vacuolisation, which allowed better discrimination between...Continue Reading

References

Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N P Luepke
Dec 1, 1974·Developmental Biology·R AuerbachJ Folkman
Jun 1, 1981·Archives of Ophthalmology·C S FosterR Giovanoni
Mar 1, 1996·The Journal of Pharmacy and Pharmacology·Y KinouchiN Yata
May 26, 1998·Environmental Health Perspectives·R D Curren, J W Harbell
Jun 7, 2002·AAPS PharmSci·Pascal FurrerRobert Gurny
Oct 27, 2004·Cornea·Bradley HughesMichael C Brodsky
Nov 3, 2005·International Journal of Pharmaceutics·Ahmed S GuinediRania M Hathout
Jan 24, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·R G AlanyN M Davies
Nov 2, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ian S ZagonPatricia J McLaughlin
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Junping LiBrenda J Tripathi
Jun 20, 2008·AAPS PharmSciTech·Ghada Abdelbary, Nashwa El-Gendy
Nov 11, 2009·Archives of Ophthalmology·Ian S ZagonPatricia J McLaughlin
Aug 18, 2010·Acta Veterinaria Hungarica·Péter BudaiEva Kormos
Jan 20, 2011·Journal of Pharmaceutical Sciences·Hamdy AbdelkaderRaid G Alany

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Citations

Apr 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saeid Moghassemi, Afra Hadjizadeh
Aug 21, 2014·Angiogenesis·Patrycja Nowak-SliwinskaM Luisa Iruela-Arispe
Dec 21, 2012·Expert Opinion on Drug Delivery·Hamed HamishehkarMaryam Kouhsoltani
Jul 6, 2014·BioMed Research International·Ranjan Ku SahooKetousetuo Kuotsu
Oct 22, 2016·Drug Delivery and Translational Research·I Bravo-OsunaR Herrero-Vanrell
Jan 28, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Zeinab M A FathallaRaid G Alany
Nov 27, 2018·Pharmaceutical Development and Technology·Mohammad Mehdi MahboobianIlva Dana Rupenthal
Mar 30, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Stephen LeeSachin S Thakur
May 18, 2019·Nanomaterials·Blanca Lorenzo-VeigaCarmen Alvarez-Lorenzo
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Hamdy AbdelkaderBarbara Pierscionek
Jun 5, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sachin S ThakurIlva D Rupenthal
Aug 29, 2020·Translational Vision Science & Technology·Carolina Nunes da SilvaArmando da Silva Cunha-Jr
Mar 16, 2019·The Journal of Pharmacology and Experimental Therapeutics·Karthik Yadav JangaSoumyajit Majumdar
Feb 6, 2021·Drug Delivery and Translational Research·Jorge JimenezMorgan V Fedorchak
Oct 17, 2020·Scientific Reports·Blessing O AnonyeFreya Harrison
Oct 30, 2020·International Journal of Nanomedicine·Ghada Ahmed El-EmamAbd El Gawad H Abd El Gawad
Dec 3, 2020·Pharmaceutics·Hamdy AbdelkaderRaid G Alany
Mar 24, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Péter BudaiJózsef Lehel
May 27, 2021·Human & Experimental Toxicology·M S SamimiM Mohammadi
Jul 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Flavia Rodrigues da SilvaPaula Santos Nunes
Aug 22, 2017·Molecular Pharmaceutics·Peter W J MorrisonVitaliy V Khutoryanskiy

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