Conjunctival provocation tests: prediction of seasonal allergy

Current Opinion in Allergy and Clinical Immunology
Julian Schröder, R Mösges

Abstract

The conjunctival provocation test (CPT) is often used to clearly identify the specific allergen causing the symptoms of allergic rhinoconjunctivitis but also to assess the clinical efficacy of an allergen immunotherapy (AIT). As there is no consensus about its predictive value, the aim of this publication is to evaluate under which conditions the CPT can predict the symptom severity during the allergy season after previous AIT. Three out of four randomized controlled trials (RCTs) showed a correlation between CPT reactivity and symptoms occurring under natural allergen exposure after previous AIT. Furthermore, one RCT found that performing the CPT 4 weeks after initiating AIT can identify early responders who also show a benefit during the season. Another RCT suggested that conducting the CPT prior to starting AIT can be used to identify patients who may benefit more from treatment than others. The assessment of the reviewed literature led us to the conclusion that the CPT has a predictive value and can consequently be used to assess the efficacy of an administered AIT if performed according to a standardized challenge protocol with high-quality allergen extracts.

References

Feb 11, 2003·International Archives of Allergy and Immunology·Herbert RiechelmannGunther Gropper
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Michael J RadcliffeStephen T Holgate
Jan 23, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Kristian KruseRalph Mösges
Feb 20, 2016·International Archives of Allergy and Immunology·Claas GloisteinRalph Mösges
Jul 20, 2016·Allergy·J-L FauquertUNKNOWN Interest Group on Ocular Allergy (IGOA) from the European Academy of Allergy and Clinical Immunology
Jul 13, 2018·Clinical and Translational Allergy·Janina KötherRalph Mösges

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Citations

Aug 4, 2020·Clinical and Translational Allergy·O Pfaar, P Zieglmayer
Nov 12, 2019·The World Allergy Organization Journal·S ZielenP J de Kam

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