Conjunctival Squamous Cell Neoplasia Associated With Ocular Cicatricial Pemphigoid

Ophthalmic Plastic and Reconstructive Surgery
Catherine J ChoiSuzanne K Freitag

Abstract

The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. One patient had a preinvasive squamous dysplasia and the other an invasive squamous cell carcinoma, both in the unequivocal setting of OCP with bilateral conjunctivitis, symblephara, and forniceal foreshortening. The patients had been receiving intensive immunotherapy consisting of some combination of corticosteroids, rituximab, and interferon alpha. Both patients had a positive immunofluorescent study demonstrating immunoreactants at the level of the epithelial basement membrane. Each patient had 2 earlier negative immunofluorescent studies before a third was positive. While rare, there is 1 previous report of an association between OCP and conjunctival squamous neoplasia. The current report provides more data supporting the proposal that this conjunctio...Continue Reading

References

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Citations

Jan 30, 2019·Ophthalmology and Therapy·Panagiotis GeorgoudisZisis Gatzioufas
Aug 28, 2020·JAMA Ophthalmology·Cherie A FathyZeba A Syed
Jul 22, 2018·Ophthalmology and Therapy·Maria Vittoria CicinelliGiulio Modorati

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