Connected Language in Late Middle-Aged Adults at Risk for Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Kimberly D MuellerSterling C Johnson


Connected language is often impaired among people with Alzheimer's disease (AD), yet little is known about when language difficulties first emerge on the path to a clinical diagnosis. The objective of this study was to determine whether individuals with psychometric (preclinical) evidence of amnestic mild cognitive impairment (pMCI) showed deficits in connected language measures. Participants were 39 pMCI and 39 cognitively healthy (CH) adults drawn from the Wisconsin Registry for Alzheimer's Prevention, who were matched for age, literacy, and sex. Participants completed a connected language task in which they described the Cookie Theft picture from the Boston Diagnostic Aphasia Examination. Language samples were analyzed across three language domains: content, syntactic complexity, and speech fluency. Paired t-tests were used to compare CH and pMCI groups on all variables, and Cohen's d effect sizes were calculated for each comparison. The CH and pMCI groups differed significantly on measures of content (e.g., CH group produced more semantic units, more unique words and had larger idea density, on average, than the pMCI group). The picture description findings are consistent with previous retrospective studies showing semantic...Continue Reading


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Dec 1, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kimberly D MuellerLyn S Turkstra
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Mar 20, 2020·Journal of Speech, Language, and Hearing Research : JSLHR·Kevin T Cunningham, Katarina L Haley
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Aug 15, 2018·Journal of Alzheimer's Disease : JAD·Antoine SlegersSimona Maria Brambati
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