Connecting phenotype and chemotype: high-content discovery strategies for natural products research

Journal of Natural Products
Kenji L Kurita, Roger G Linington

Abstract

In recent years, the field of natural products has seen an explosion in the breadth, resolution, and accuracy of profiling platforms for compound discovery, including many new chemical and biological annotation methods. With these new tools come opportunities to examine extract libraries using systematized profiling approaches that were not previously available to the field and which offer new approaches for the detailed characterization of the chemical and biological attributes of complex natural products mixtures. This review will present a summary of some of these untargeted profiling methods and provide perspective on the future opportunities offered by integrating these tools for novel natural products discovery.

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Citations

Mar 15, 2016·Expert Opinion on Drug Discovery·Ivan Fraietta, Fabio Gasparri
Jul 23, 2016·Journal of Natural Products·Marie-Laure VialRonald J Quinn
Mar 11, 2017·Journal of Natural Products·Alexander E Fox RamosMehdi A Beniddir
Mar 10, 2017·Expert Opinion on Drug Discovery·Mingzi M ZhangHuimin Zhao
Nov 23, 2016·Natural Product Reports·Neha GargVanessa V Phelan
Oct 3, 2017·Annual Review of Pharmacology and Toxicology·Asmaa Boufridi, Ronald J Quinn
Mar 13, 2019·Chinese Medicine·Jing WangJia-Hong Lu
Dec 24, 2020·Nature Reviews. Drug Discovery·Srinivas Niranj ChandrasekaranAnne E Carpenter
Aug 23, 2017·ACS Chemical Biology·Florent OlivonMarc Litaudon

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