Connecting the dots: an association between opioids and acute hippocampal injury

Neurocase
Jed A Barash, W Andrew Kofke

Abstract

Acute hippocampal injury represents a relatively rare cause of amnesia. Interestingly however, between 2012 and 2017, 18 patients were reported at hospitals in Massachusetts with sudden-onset amnesia in the setting of complete diffusion-weighted hyperintensity of both hippocampi on magnetic resonance imaging. Notably, 17 of the 18 patients tested positive for opioids or had a recorded history of opioid use. This observation suggests an association between opioids and acute hippocampal injury. With particular attention to the Massachusetts cluster and data on fentanyl and its congeners, the epidemiological and pathophysiological evidence that supports this hypothesis is presented, as are potential underlying mechanisms.

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Citations

Nov 7, 2018·Annals of Internal Medicine·Uzoma B DuruMarc W Haut
Jun 11, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·P Monroe ButlerBruce L Miller
Feb 18, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aaron R SwitzerGerald Pfeffer
Dec 29, 2020·Addictive Behaviors Reports·Xin ZhaoJoseph H R Maes
Sep 15, 2020·Harvard Review of Psychiatry·Blaise A AguirreJed A Barash
Sep 3, 2021·Curēus·William Ciurylo, Elizabeth Noh

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