Connecting the dots between SHP2 and glutamate receptors

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Hyun-Hee RyuYong-Seok Lee

Abstract

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological and pathophysiological roles of SHP2 have been extensively studied in the field of cancer research. Mutations in the PTPN11 gene which encodes SHP2 are also highly associated with developmental disorders, such as Noonan syndrome (NS), and cognitive deficits including learning disabilities are common among NS patients. However, the molecular and cellular mechanism by which SHP2 is involved in cognitive functions is not well understood. Recent studies using SHP2 mutant mice or pharmacological inhibitors have shown that SHP2 plays critical role in learning and memory and synaptic plasticity. Here, we review the recent studies demonstrating that SHP2 is involved in synaptic plasticity, and learning and memory, by the regulation of the expression and/or function of glutamate receptors. We suggest that each cell type may have distinct paths connecting the dots between SHP2 and glutamate receptors, and these paths may also change with aging.

References

Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S P ButcherR G Morris
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S AhmadS H Shen
Dec 1, 1994·Nature Genetics·C R JamiesonE Mariman
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Mar 10, 1998·Cell·P HofS E Shoelson
May 18, 2000·Nature Neuroscience·C LüscherD Muller
Jun 22, 2000·Nature Neuroscience·H HusiS G Grant
Oct 24, 2002·Trends in Neurosciences·Reed C Carroll, R Suzanne Zukin
Jun 27, 2003·Trends in Biochemical Sciences·Benjamin G NeelLily Pao
Aug 19, 2003·The Journal of Biological Chemistry·Toshiyuki ArakiBenjamin G Neel
Mar 25, 2004·Journal of Cellular Physiology·Christina Ivins ZitoAnton M Bennett
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric E ZhangGen-Sheng Feng
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Marco Tartaglia, Bruce D Gelb
Dec 27, 2005·The Journal of Biological Chemistry·Maria I KontaridisBenjamin G Neel
Oct 4, 2006·The Journal of Cell Biology·Mara FornaroAnton M Bennett
Dec 21, 2007·Nature Reviews. Neuroscience·Guilherme NevesTim V P Bliss
Jan 21, 2009·Nature Reviews. Neuroscience·Yong-Seok Lee, Alcino J Silva
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Toshiyuki ArakiBenjamin G Neel
May 1, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ruth L Stornetta, J Julius Zhu
Jun 11, 2010·Nature·Xonia Carvajal-VergaraIhor R Lemischka
Sep 30, 2010·Pediatrics·Alicia A RomanoJacqueline A Noonan
Feb 23, 2011·The Journal of Clinical Investigation·Talita M MarinMaria I Kontaridis
Nov 5, 2011·Trends in Neurosciences·Hiroshi OhnishiTakashi Matozaki
Nov 5, 2011·Science·Victoria M HoKelsey C Martin
Aug 7, 2013·American Journal of Medical Genetics. Part a·Elizabeth I PierpontAmy E Roberts
Oct 9, 2013·Journal of Medical Genetics·Brigid AdvientoLauren A Weiss
Nov 5, 2013·Neuron·Richard L Huganir, Roger A Nicoll
Nov 11, 2014·Nature Neuroscience·Yong-Seok LeeAlcino J Silva

❮ Previous
Next ❯

Citations

Nov 9, 2021·Frontiers in Molecular Biosciences·Hani SabaieMaryam Rezazadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.