Connecting the "Dots": From Free Radical Lipid Autoxidation to Cell Pathology and Disease.

Chemical Reviews
Morgan K ForetGonzalo Cosa

Abstract

Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is increasingly implicated in various diseases but also recognized as a key part of normal cell function, signaling, and death (ferroptosis). Not surprisingly, the root and consequences of lipid peroxidation have garnered increasing attention from multiple disciplines in recent years. Here we "connect the dots" between the fundamental chemistry underpinning the cascade reactions of lipid peroxidation (enzymatic or free radical), the reactive nature of the products formed (lipid-derived electrophiles), and the biological targets and mechanisms associated with these products that culminate in cellular responses. We additionally bring light to the use of highly sensitive, fluorescence-based methodologies. Stemming from the foundational concepts in chemistry and biology, these methodologies enable visualizing and quantifying each reaction in the cascade in a cellular and ultimately tissue context, toward deciphering the connections between the chemistry and physiology of lipid peroxidation. The review offers a platform in which the chemistry and biomedical research communities can access a comprehensive summary of fundamental concepts regardi...Continue Reading

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Citations

May 18, 2021·Free Radical Biology & Medicine·Julia Bahja, Marcus K Dymond
Aug 31, 2021·RSC Medicinal Chemistry·Maximillian Taro William LeeMark David Rackham
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qun GuanYu-Bin Dong

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