Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis - Potential roles of placental ACE2 and ENDOU.

Placenta
Hongwu JingIrina A Buhimschi

Abstract

We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU's relevance to vertical transmission of SARS-CoV-2 is further warranted.

References

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Citations

Mar 24, 2021·SN Comprehensive Clinical Medicine·Nevio Cimolai
Apr 29, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jennifer Jardine, Edward Morris
Sep 6, 2021·American Journal of Obstetrics and Gynecology·UNKNOWN Research CommitteeUNKNOWN SMFM Research Committee. Electronic address: smfm@smfm.org

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Datasets Mentioned

BETA
GSE73714

Methods Mentioned

BETA
RNAseq

Software Mentioned

R
DyNet Analyzer
DESeq2
STRING
Cytoscape

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