Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.

Immunological Reviews
Stephen P CobboldHerman Waldmann

Abstract

A variety of different molecular mechanisms have been proposed to explain the suppressive action of regulatory T cells, including the production of anti-inflammatory cytokines, negative costimulatory ligands, indoleamine 2,3-dioxygenase-mediated tryptophan catabolism, CD73-mediated adenosine generation, and downregulation of antigen-presenting cells. Until now it has been unclear how important each of these different mechanisms might be and how they are coordinated. In this review, we examine the hypothesis that it is the interaction between regulatory T cells and dendritic cells that creates a local microenvironment depleted of essential amino acids and rich in adenosine that leads to the amplification of a range of different tolerogenic signals. These signals are all eventually integrated by mammalian target of rapamycin inhibition, which enables the induction of new forkhead box protein 3-expressing Tregs. If correct, this provides a molecular explanation for the in vivo phenomena of linked suppression and infectious tolerance.

References

Jan 1, 1975·Transplantation Reviews·R K Gershon
Apr 1, 1992·Journal of Autoimmunity·H WaldmannS Cobbold
Dec 1, 1990·European Journal of Immunology·S X QinH Waldmann
Mar 1, 1989·The Journal of Experimental Medicine·S X QinH Waldmann
Feb 12, 1993·Science·S QinH Waldmann
Jun 10, 1994·Science·G LombardiR Lechler
Mar 4, 1999·European Journal of Immunology·J G ChaiR Lechler
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diana ZelenikaHerman Waldmann
Aug 15, 2002·Current Biology : CB·Jing DengNahum Sonenberg
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Nov 1, 2002·Cell·Wayne A Wilson, Peter J Roach
May 3, 2003·Annals of the New York Academy of Sciences·Ralph M SteinmanMichel Nussenzweig
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Nov 18, 2003·Immunological Reviews·Stephen P CobboldHerman Waldmann
Dec 24, 2003·Seminars in Immunology·Stephen P CobboldHerman Waldmann
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tse-Ching ChenHerman Waldmann
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen P CobboldHerman Waldmann
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Roger LehmannGiatgen Andreia Spinas
Jun 23, 2004·Advances in Experimental Medicine and Biology·Francesca FallarinoPaolo Puccetti
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong ZhangDavid W Hoskin
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Timuçin TanerAngus W Thomson
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Edwin H PrestonAllan D Kirk
Aug 2, 2005·Cell Metabolism·Anne-Catherine MaurinPierre Fafournoux
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Feb 8, 2006·Current Opinion in Immunology·David H Munn
Mar 22, 2006·Expert Opinion on Biological Therapy·Mahyar Nouri-Shirazi, Angus W Thomson
May 9, 2006·Nature Immunology·Stefanie ScheuRichard M Locksley
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Sep 16, 2006·Immunological Reviews·Stephen P CobboldHerman Waldmann
Oct 7, 2006·Blood·Paulo C RodriguezAugusto C Ochoa
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura StraussAlfred Zippelius

❮ Previous
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Citations

Dec 30, 2011·Cellular and Molecular Life Sciences : CMLS·David M Gravano, Dario A A Vignali
Sep 18, 2012·Immunologic Research·Tao YangHoward W Davidson
Jul 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lisa O'FlynnThomas Ritter
Nov 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tom Simones, David M Shepherd
Jun 11, 2011·Journal of Translational Medicine·M Naranjo-GómezFrancesc E Borràs
Jul 16, 2013·PLoS Pathogens·Antonella De LucaLuigina Romani
Dec 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Roberto A MaldonadoTakashi Kei Kishimoto
Aug 15, 2012·Immunological Reviews·Tracy L McGahaAndrew L Mellor
Jul 20, 2010·Immunological Reviews·Philippa MarrackMegan K L MacLeod
Sep 14, 2014·Seminars in Nephrology·Rafael Kramann, Benjamin D Humphreys
Jan 15, 2015·Trends in Immunology·Lucy S K Walker, David M Sansom
Jun 5, 2013·Human Vaccines & Immunotherapeutics·Ayssa A SelfStephen H Gregory
Oct 19, 2012·Virulence·Phyllis T LosikoffStephen H Gregory
Jun 20, 2015·PLoS Computational Biology·Mariana Esther Martinez-SanchezElena R Alvarez-Buylla
Oct 16, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Grant P ParnellDavid R Booth
Mar 25, 2017·Journal of Chemotherapy·Franco AversaAndrea Novelli
Mar 28, 2017·Molecular Therapy. Methods & Clinical Development·Shamael R DastagirRémi J Creusot
Oct 14, 2014·Pediatric Research·W Allan Walker, Rajashri Shuba Iyengar
Nov 19, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuri V Bobryshev
Apr 3, 2014·The Journal of Clinical Investigation·Herman WaldmannStephen Cobbold
Feb 24, 2011·Expert Review of Anti-infective Therapy·Melanie R Power CoombsOfer Levy
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Babak BabanAndrew L Mellor
Dec 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert SucherGerald Brandacher
Sep 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brendan J O'SullivanRanjeny Thomas
Jul 1, 2011·Clinical Pharmacology and Therapeutics·A M AzimzadehJ S Bromberg
Jun 15, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taba KheradmandXunrong Luo
Dec 14, 2018·Nature Communications·Song ChenXiaoming Feng
Jul 14, 2020·Frontiers in Immunology·Juliette KropMichael Eikmans
Apr 21, 2012·Nature Reviews. Immunology·Hongbo Chi
May 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmar Von BubnoffThomas Bieber
Jan 5, 2021·The Journal of Clinical Investigation·Ashley N SuahAnita S Chong
Oct 13, 2020·International Immunopharmacology·Jianrui ZengHuabao Xiong
Oct 12, 2016·Microbiology Spectrum·Herman WaldmannStephen Cobbold

❮ Previous
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