Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting.

American Journal of Physiology. Renal Physiology
Hong WangOscar A Carretero

Abstract

Tubuloglomerular feedback (TGF) and connecting tubule glomerular feedback (CTGF) are mechanisms that control afferent arteriole (Af-Art) tone. TGF, initiated by increased NaCl at the macula densa, causes Af-Art constriction. Prolonged activation of TGF leads to an attenuation or "resetting" of its constrictor effect. The mechanisms of TGF resetting remain incompletely understood. CTGF is initiated by increased NaCl in the connecting tubule and Na(+) entry via epithelial sodium channels (ENaC). Contrary to TGF, CTGF dilates the Af-Art. Here, we hypothesize that CTGF, in part, mediates TGF resetting. We performed micropuncture of individual rat nephrons while measuring stop-flow pressure (P(SF)), an index of glomerular filtration pressure and Af-Art tone. Increases in Af-Art tone cause P(SF) to decrease. TGF responses, measured as the decrease in P(SF) induced by switching late proximal tubule perfusion from 5 to 40 nl/min, were elicited before and after a 30-min period of sustained perfusion of the late proximal tubule at a rate of 40 nl/min designed to induce TGF resetting. TGF responses were 7.3 ± 0.3 and 4.9 ± 0.2 mmHg before and after resetting was induced (P < 0.001, n = 6). When CTGF was inhibited with the ENaC blocker ben...Continue Reading

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Citations

Mar 12, 2013·Antioxidants & Redox Signaling·Magali Araujo, Christopher S Wilcox
Sep 26, 2013·Hypertension·Yilin RenOscar A Carretero
Aug 21, 2013·Hypertension·Hong WangOscar A Carretero
Nov 1, 2018·American Journal of Physiology. Renal Physiology·Scott C Thomson
Mar 7, 2019·American Journal of Physiology. Renal Physiology·Cesar A Romero, Oscar A Carretero
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Feb 27, 2015·American Journal of Physiology. Renal Physiology·Hong WangOscar A Carretero
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Nov 28, 2013·Current Opinion in Nephrology and Hypertension·L Gabriel Navar
Nov 22, 2013·American Journal of Physiology. Renal Physiology·Prabhleen Singh, Scott C Thomson

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