Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor

Biological Psychiatry
Kelsey ZimmermannShannon L Gourley

Abstract

Distinguishing between actions that are more likely or less likely to be rewarded is a critical aspect of goal-directed decision making. However, neuroanatomic and molecular mechanisms are not fully understood. We used anterograde tracing, viral-mediated gene silencing, functional disconnection strategies, pharmacologic rescue, and designer receptors exclusively activated by designer drugs (DREADDs) to determine the anatomic and functional connectivity between the orbitofrontal cortex (OFC) and the amygdala in mice. In particular, we knocked down brain-derived neurotrophic factor (Bdnf) bilaterally in the OFC or generated an OFC-amygdala "disconnection" by pairing unilateral OFC Bdnf knockdown with lesions of the contralateral amygdala. We characterized decision-making strategies using a task in which mice selected actions based on the likelihood that they would be reinforced. Additionally, we assessed the effects of DREADD-mediated OFC inhibition on the consolidation of action-outcome conditioning. As in other species, the OFC projects to the basolateral amygdala and dorsal striatum in mice. Bilateral Bdnf knockdown within the ventrolateral OFC and unilateral Bdnf knockdown accompanied by lesions of the contralateral amygdala ...Continue Reading

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Citations

Mar 24, 2016·Neurobiology of Learning and Memory·Kelsey S ZimmermannShannon L Gourley
Jan 17, 2017·Biological Psychiatry·Trevor W Robbins
Dec 1, 2017·Nature Communications·Andrew M SwansonShannon L Gourley
Jul 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kelsey S ZimmermannShannon L Gourley
Mar 16, 2018·Scientific Reports·Elizabeth G PittsShannon L Gourley
Sep 17, 2019·Annual Review of Vision Science·Emmanouil FroudarakisAndreas S Tolias
Dec 11, 2019·Journal of Neuroscience Research·Ellen P WoonShannon L Gourley
Jun 21, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elizabeth G PittsShannon L Gourley
Nov 7, 2019·Journal of Neuroscience Research·Melissa Malvaez
Jun 23, 2020·Addiction Biology·Rachel D AltshulerXuan Li
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Marco EmiliFiorenza Stagni
Apr 10, 2019·Nature Neuroscience·Shannon L Gourley
Apr 10, 2019·Nature Neuroscience·Melissa MalvaezKate M Wassum
Dec 12, 2019·Translational Psychiatry·Andrew DieterichBenjamin A Samuels
Apr 26, 2016·Nature Neuroscience·Shannon L Gourley, Jane R Taylor
Jul 19, 2019·Biology of Sex Differences·Sierra J StringfieldDonita L Robinson
Jul 25, 2020·Neuroscience and Biobehavioral Reviews·Karly M Turner, Shauna L Parkes
Oct 10, 2020·Neuroscience and Biobehavioral Reviews·Elizabeth E ManningMihaela D Iordanova
Sep 10, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel J Smith, Lillian S Laiks
Apr 25, 2021·Neuron·Pierre Le MerreMarie Carlén

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