Connective Tissue Disease-associated Interstitial Lung Diseases (CTD-ILD) - Report from OMERACT CTD-ILD Working Group

The Journal of Rheumatology
D KhannaV Strand

Abstract

Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research. The CTD-ILD working group, under the aegis of the Outcome Measures in Rheumatology (OMERACT) initiative, has completed a consensus group exercise to reach harmony on core domains and items for inclusion in RCT in CTD-ILD. During the OMERACT 12 meeting, consensus was sought on domains and core items for inclusion in RCT. In addition, consensus was pursued on a definition of response in RCT. Consensus was defined as ≥ 75% agreement among the participants. OMERACT 12 participants endorsed the domains with minimal modifications. Clinically meaningful progression for CTD-ILD was proposed as ≥ 10% relative decline in forced vital capacity (FVC) or ≥ 5% to < 10% relative decline in FVC and ≥ 15% relative decline in DLCO. There is consensus on domains for inclusion in RCT in CTD-ILD and on a definition of clinically meaningful prog...Continue Reading

Associated Clinical Trials

References

Jun 23, 2006·The New England Journal of Medicine·Donald P TashkinUNKNOWN Scleroderma Lung Study Research Group
Aug 25, 2007·American Journal of Respiratory and Critical Care Medicine·Donald P TashkinUNKNOWN Scleroderma Lung Study Research Group
Aug 21, 2012·The European Respiratory Journal·Carlo Vancheri, Roland M du Bois
Jan 31, 2014·American Journal of Respiratory and Critical Care Medicine·Talmadge E KingPaul W Noble
Mar 4, 2014·Journal of Clinical Epidemiology·Maarten BoersPeter Tugwell

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Citations

Aug 16, 2016·Chest·Ayodeji Adegunsoye, Mary E Strek
May 30, 2017·Chest·Tracy J Doyle, Paul F Dellaripa
Apr 11, 2018·Current Rheumatology Reports·Christopher A Mecoli, Lisa Christopher-Stine
Jan 29, 2016·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Hidekata Yasuoka
Jun 29, 2018·Expert Review of Clinical Immunology·Nicolò Pipitone, Carlo Salvarani
Aug 22, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Margaret Wilsher
Dec 24, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Jeffrey J SwigrisYoshikazu Inoue
May 18, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Melissa CaronRussell Steele
Aug 16, 2019·Current Opinion in Rheumatology·Daniel J DeMizio, Elana J Bernstein
Jul 17, 2019·American Journal of Respiratory and Critical Care Medicine·Anna-Maria Hoffmann-VoldØyvind Molberg
Aug 31, 2019·Immunological Investigations·Jianjian GeYurong Tang
May 23, 2019·Multidisciplinary Respiratory Medicine·Nicola CiancioGianluca Sambataro
Sep 20, 2019·Rheumatology·Sabrina HoaUNKNOWN Canadian Scleroderma Research Group
Mar 15, 2019·Current Opinion in Rheumatology·David RoofehDinesh Khanna
Jun 9, 2020·Expert Review of Clinical Immunology·Yoshioki Yamasaki, Masataka Kuwana
Sep 6, 2020·Current Opinion in Rheumatology·Anna-Maria Hoffmann-Vold, Øyvind Molberg
Jul 15, 2017·The Korean Journal of Internal Medicine·So-My Koo, Soo-Taek Uh
Mar 27, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Atsushi SuzukiYoshinori Hasegawa
Jun 23, 2020·Expert Review of Respiratory Medicine·Paroma SarkarNazia Chaudhuri
Aug 3, 2019·The Journal of Rheumatology·Lyn MarchPeter Tugwell
Jan 31, 2020·Respiratory Research·Alyson W WongSabina A Guler

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