Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia

NeuroImage. Clinical
Rachael G GraziopleneTyrone D Cannon

Abstract

Reduced fractional anisotropy (FA) is a well-established correlate of schizophrenia, but it remains unclear whether these tensor-based differences are the result of axon damage and/or organizational changes and whether the changes are progressive in the adult course of illness. Diffusion MRI data were collected in 81 schizophrenia patients (54 first episode and 27 chronic) and 64 controls. Analysis of FA was combined with "fixel-based" analysis, the latter of which leverages connectivity and crossing-fiber information to assess both fiber bundle density and organizational complexity (i.e., presence and magnitude of off-axis diffusion signal). Compared with controls, patients with schizophrenia displayed clusters of significantly lower FA in the bilateral frontal lobes, right dorsal centrum semiovale, and the left anterior limb of the internal capsule. All FA-based group differences overlapped substantially with regions containing complex fiber architecture. FA within these clusters was positively correlated with principal axis fiber density, but inversely correlated with both secondary/tertiary axis fiber density and voxel-wise fiber complexity. Crossing fiber complexity had the strongest (inverse) association with FA (r = -0.8...Continue Reading

Citations

Jun 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Vanessa KraguljacAdrienne Carol Lahti
Mar 7, 2019·Frontiers in Human Neuroscience·Gemma B NorthamFrédérique J Liégeois
Mar 21, 2019·Frontiers in Neuroinformatics·Gregory KiarAlan C Evans
Jan 29, 2019·Frontiers in Neuroscience·Óscar Peña-NogalesLuca Giancardo
Apr 25, 2020·Frontiers in Aging Neuroscience·Hamsanandini RadhakrishnanCraig E L Stark
Jan 10, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Angeliki ZarkaliRimona S Weil
Dec 14, 2021·Frontiers in Neuroscience·Karthik CharyAlejandra Sierra

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Software Mentioned

Fixel
dwi2tensor
mrclusterstats
MRtrix
EDDY
FMRIB Software Library ( FSL
mrconvert
dtifit
Randomise
TBSS

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